Intermediate of MK-8245

Base Information

• Chemical Name: Intermediate of MK-8245
• CAS No.: 916889-25-3
• Molecular Formula: C₁₁H₁₃BrFNO*ClH
• Molecular Weight: 310.594

Synonyms:

Chemical Property of Intermediate of MK-8245

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Intermediate of MK-8245

There total 2 articles about Intermediate of MK-8245 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(2-bromo-5-fluorophenoxy)piperidine-1-carboxylate (1006878-92-7) → 4-(2-bromo-5-fluorophenoxy)piperidine hydrochloride (916889-25-3)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 12h;

Reference yield:

→ 4-(2-bromo-5-fluorophenoxy)piperidine hydrochloride (916889-25-3)

Guidance literature:

Reference yield:

4-(2-bromo-5-fluorophenoxy)piperidine hydrochloride (916889-25-3) + 5-Bromo-2-chloropyrimidine (32779-36-5) → 5-bromo-2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrimidine (1042428-78-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 120 ℃; for 3h;

upstream raw materials:

tert-butyl 4-(2-bromo-5-fluorophenoxy)piperidine-1-carboxylate

Downstream raw materials:

4-(2-bromo-5-fluorophenoxy)piperidine

5-bromo-2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrimidine

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