5-Aminopiperidin-2-one hydrochloride

Base Information

Chemical Name:5-Aminopiperidin-2-one hydrochloride
CAS No.:154148-70-6
Molecular Formula:C5H11ClN2O
Molecular Weight:114.15
Hs Code.:2933790090
DSSTox Substance ID:DTXSID30677628
Mol file:154148-70-6.mol

Synonyms:5-aminopiperidin-2-one hydrochloride;1235440-18-2;5-AMINO-PIPERIDIN-2-ONE HYDROCHLORIDE;5-aminopiperidin-2-one;hydrochloride;MFCD09743647;(S)-5-Amino-piperidin-2-one HCl;(R)-5-Amino-2-piperidone Hydrochloride;5-aminopiperidin-2-one HCl;SCHEMBL3203237;DTXSID30677628;KFJLLOJCPFYWRV-UHFFFAOYSA-N;5-aminopiperidin-2-onehydrochloride;AMY24060;5-aminopiperidin-2-one,hydrochloride;AKOS015949429;PB22229;SB10553;SB15585;SB15586;rac-5-aminopiperidin-2-one hydrochloride;AS-33735;SY022821;SY036453;CS-0050676;EN300-62191;2-Piperidinone, 5-amino-, hydrochloride (1:1);5-Aminopiperidin-2-one--hydrogen chloride (1/1);A890686;J-502474;W-205760;F8888-7478;Z992717028

Suppliers and Price of 5-Aminopiperidin-2-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-aminopiperidin-2-one
100mg
$ 155.00

Matrix Scientific
5-Aminopiperidin-2-one 95%+
1g
$ 467.00

Matrix Scientific
5-Aminopiperidin-2-one 95%+
2.500g
$ 1021.00

Matrix Scientific
5-Aminopiperidin-2-one 95%+
5g
$ 1545.00

Crysdot
5-Aminopiperidin-2-one 95+%
25g
$ 4286.00

Crysdot
5-Aminopiperidin-2-one 95+%
10g
$ 2247.00

Crysdot
5-Aminopiperidin-2-one 95+%
5g
$ 1280.00

Crysdot
5-Aminopiperidin-2-one 95+%
1g
$ 431.00

Chemenu
5-Aminopiperidin-2-one 95%
1g
$ 407.00

Chemenu
5-Aminopiperidin-2-one 95%
5g
$ 1206.00

Total 22 raw suppliers

Chemical Property of 5-Aminopiperidin-2-one hydrochloride

Chemical Property:

Boiling Point:307.5±35.0 °C(Predicted)
PKA:16.00±0.40(Predicted)
PSA：55.12000
Density:1.071±0.06 g/cm3(Predicted)
LogP:1.05480
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:150.0559907
Heavy Atom Count:9
Complexity:103

Purity/Quality:

97% ^*data from raw suppliers

5-aminopiperidin-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NCC1N.Cl
Uses 5-Aminopiperidin-2-one can be prepared to use as CDK inhibitors to treat cancer.

Technology Process of 5-Aminopiperidin-2-one hydrochloride

There total 6 articles about 5-Aminopiperidin-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 172913-96-1,1228566-94-6
(5S)-5-[(tert-butoxycarbonyl)amino]piperidin-2-one

: 154148-70-6
(S)-5-aminopiperidin-2-one

Guidance literature:: With trifluoroacetic acid;
DOI:10.1016/00404-0399(50)17557-

Reference yield:

: 91229-98-0
1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-piperidone

: 154148-70-6
(S)-5-aminopiperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 1.) hydrogen; 2.) TiCl₃ / 1.) Pd/C

2: 98 percent / trifluoroacetic acid

With titanium(III) chloride; hydrogen; trifluoroacetic acid; palladium on activated charcoal;
DOI:10.1016/00404-0399(50)17557-

Reference yield:

: 91229-96-8
(4S)-N-benzyloxy-4-(N-tert-butoxycarbonyl)amino-5-hydroxypentanamide

: 154148-70-6
(S)-5-aminopiperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: PPh₃, DEAD / 50 °C

2: 80 percent / 1.) hydrogen; 2.) TiCl₃ / 1.) Pd/C

3: 98 percent / trifluoroacetic acid

With titanium(III) chloride; hydrogen; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal;
DOI:10.1016/00404-0399(50)17557-