4-PHENYL-1H-PYRAZOL-5-AMINE

Base Information

• Chemical Name: 4-PHENYL-1H-PYRAZOL-5-AMINE
• CAS No.: 57999-06-1
• Molecular Formula: C9H9N3
• Molecular Weight: 159.191
• Mol file: 57999-06-1.mol

Synonyms:BUTTPARK 49\07-31;AKOS B035600;4-PHENYL-2H-PYRAZOL-3-YLAMINE;1H-Pyrazol-5-amine, 4-phenyl;4-phenyl-1H-pyrazol-5-ylamine;

Chemical Property of 4-PHENYL-1H-PYRAZOL-5-AMINE

Chemical Property:

• Vapor Pressure: 1.99E-06mmHg at 25°C
• Melting Point: 175-177
• Boiling Point: 394.4°C at 760 mmHg
• Flash Point: 220.9°C
• PSA: 54.70000
• Density: 1.238g/cm³
• LogP: 2.24010

Purity/Quality:

99% ^*data from raw suppliers

5-AMINO-4-PHENYL-1H-PYRAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PHENYL-1H-PYRAZOL-5-AMINE

There total 9 articles about 4-PHENYL-1H-PYRAZOL-5-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-phenyl-3-piperidin-1-ylacrylonitrile → 4-phenyl-1H-pyrazol-5-amine (57999-06-1)

Guidance literature:

With hydrazine hydrate; acetic acid; for 0.0166667h; under 760.051 Torr; Microwave irradiation; Green chemistry;

Reference yield:

α-phenyl β-dimethylaminoacrylonitrile (70205-70-8,70515-61-6,18226-50-1) → 4-phenyl-1H-pyrazol-5-amine (57999-06-1)

Guidance literature:

With hydrazine monohydrobromide; In ethanol; water; at 110 ℃; for 5h;

DOI:10.1016/j.bmcl.2008.06.052

Reference yield:

3-nitro-4-phenyl-1H-pyrazole (51460-38-9) → 4-phenyl-1H-pyrazol-5-amine (57999-06-1)

Guidance literature:

With ethanol; platinum; Hydrogenation;

DOI:10.1021/ja01154a051

upstream raw materials:

3-nitro-4-phenyl-1H-pyrazole

2-dimethylaminomethylene-2-phenylacetonitrile

phenylacetonitrile

α-phenyl β-dimethylaminoacrylonitrile

Downstream raw materials:

7-hydroxy-3-phenyl-5-(β-pyridyl)-pyrazolo<1,5-a>pyrimidine

7-amino-5-methyl-3,6-diphenylpyrazolo<1,5-a>pyrimidine

5-trifluoromethyl-3,7-diphenylpyrazolo<1,5-a>pyrimidine

3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one