N-[(1R)-1-phenyl-2-piperidin-1-ylethyl]propan-2-amine

Base Information

• Chemical Name: N-[(1R)-1-phenyl-2-piperidin-1-ylethyl]propan-2-amine
• CAS No.: 129157-10-4
• Molecular Formula: C16H26N2
• Molecular Weight: 246.39
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20428823
• Nikkaji Number: J837.525I
• Wikidata: Q82241655
• Mol file: 129157-10-4.mol

Synonyms:129157-10-4;N-[(1R)-1-phenyl-2-piperidin-1-ylethyl]propan-2-amine;(R)-(+)-N-ISOPROPYL-1-PHENYL-2-(1-PIPERIDINO)ETHYLAMINE;(R)-(-)-N-Isopropyl-1-phenyl-2-(1-piperidinyl)ethylamine;(R)-N-(1-Phenyl-2-(piperidin-1-yl)ethyl)propan-2-amine;(R)-N-Isopropyl-1-phenyl-2-piperidinoethanamine;SBB059554;((1R)-1-phenyl-2-piperidylethyl)(methylethyl)amine;SCHEMBL14438343;DTXSID20428823;MFCD06799074;AKOS022180606;(R)-(+)-N-Isopropyl-1-phenyl-2-(1-piperidino)ethylamine, AldrichCPR

Chemical Property of N-[(1R)-1-phenyl-2-piperidin-1-ylethyl]propan-2-amine

Chemical Property:

• Vapor Pressure: 8E-05mmHg at 25°C
• Refractive Index: 1.5090
• Boiling Point: 341.5°C at 760 mmHg
• Flash Point: 115.6°C
• PSA: 15.27000
• Density: 0,931 g/cm3
• LogP: 3.54040
• Sensitive.: Air Sensitive
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 246.209598838
• Heavy Atom Count: 18
• Complexity: 215

Purity/Quality:

99% ^*data from raw suppliers

(R)-N-(1-Phenyl-2-(piperidin-1-yl)ethyl)propan-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: R34:Causes burns.
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NC(CN1CCCCC1)C2=CC=CC=C2
• Isomeric SMILES: CC(C)N[C@@H](CN1CCCCC1)C2=CC=CC=C2

Technology Process of N-[(1R)-1-phenyl-2-piperidin-1-ylethyl]propan-2-amine

There total 13 articles about N-[(1R)-1-phenyl-2-piperidin-1-ylethyl]propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R)-N-isopropyl-1-phenyl-2-piperidinoethylamine dipicrate → (R)-N-isopropyl-1-phenyl-2-(1-piperidino)ethylamine (129157-10-4)

Guidance literature:

With sodium carbonate;

DOI:10.1016/S0040-4020(97)00288-3

Reference yield: 82.0%

1-((R)-2-isopropylamino-2-phenylethanoyl)piperidine (129176-84-7) → (R)-N-isopropyl-1-phenyl-2-(1-piperidino)ethylamine (129157-10-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4020(01)81078-4

Reference yield:

(R)-1-phenyl-2-(1-piperidinyl)ethanol (40116-77-6) + isopropylamine (75-31-0) → (R)-N-isopropyl-1-phenyl-2-(1-piperidino)ethylamine (129157-10-4) + (S)-N-isopropyl-1-phenyl-2-(1-piperidinyl)ethanamine

Guidance literature:

(R)-1-phenyl-2-(1-piperidinyl)ethanol; With methanesulfonyl chloride; triethylamine; In diethyl ether; for 0.5h;

isopropylamine; With water; triethylamine; In diethyl ether; at 20 ℃; for 16h; Title compound not separated from byproducts;

DOI:10.1055/s-2001-12768

upstream raw materials:

1-((R)-2-isopropylamino-2-phenylethanoyl)piperidine

(R)-(-)-1-(2-amino-2-phenylethyl)piperidine

acetone

(R)-1-phenyl-2-(1-piperidinyl)ethanol