(5S,6S)-DIHYDROXY-(7E,9E,11Z,14Z)-EICOSATETRAENOIC ACID

Base Information

Chemical Name:(5S,6S)-DIHYDROXY-(7E,9E,11Z,14Z)-EICOSATETRAENOIC ACID
CAS No.:82948-88-7
Molecular Formula:C20H32O4
Molecular Weight:336.47
Hs Code.:2918199090
Mol file:82948-88-7.mol

Synonyms:[5S,6S]-DIHETE;5(S),6(R)-DIHETE;5S,6R-DIHYDROXY-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID;5(S),6(R)-DIHYDROXYEICOSA-7E,9E,11Z,14Z-TETRAENOIC ACID;(5S,6S)-DIHYDROXY-(7E,9E,11Z,14Z)-EICOSATETRAENOIC ACID;

Suppliers and Price of (5S,6S)-DIHYDROXY-(7E,9E,11Z,14Z)-EICOSATETRAENOIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5(S),6(R)-DiHETE
50μg
$ 175.00

Cayman Chemical
5(S),6(R)-DiHETE MaxSpec? Standard ≥95%
100μg
$ 395.00

Cayman Chemical
5(S),6(R)-DiHETE ≥98%
100μg
$ 310.00

Cayman Chemical
5(S),6(R)-DiHETE ≥98%
50μg
$ 163.00

Cayman Chemical
5(S),6(R)-DiHETE ≥98%
25μg
$ 86.00

American Custom Chemicals Corporation
5S,6R-DIHYDROXY-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID 95.00%
5MG
$ 498.33

AHH
5(S),6(R)-Dihete 98%
0.00025g
$ 488.00

Total 6 raw suppliers

Chemical Property of (5S,6S)-DIHYDROXY-(7E,9E,11Z,14Z)-EICOSATETRAENOIC ACID

Chemical Property:

PSA：77.76000
LogP:4.15830
Storage Temp.:−20°C

Purity/Quality:

≥95% ^*data from raw suppliers

5(S),6(R)-DiHETE ^*data from reagent suppliers

Safty Information:

Pictogram(s): FXi
Hazard Codes:F,Xi
Statements: 11-36/37/38
Safety Statements: 16-26-36

MSDS Files:: SDS file from LookChem

Useful:

Uses 5(S),6(R)-DiHETE is a LTD4 receptor agonist.

Technology Process of (5S,6S)-DIHYDROXY-(7E,9E,11Z,14Z)-EICOSATETRAENOIC ACID

There total 12 articles about (5S,6S)-DIHYDROXY-(7E,9E,11Z,14Z)-EICOSATETRAENOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 127939-19-9
4-[(4S,5R)-2-Oxo-5-((1E,3E,5Z,8Z)-tetradeca-1,3,5,8-tetraenyl)-[1,3]dioxolan-4-yl]-butyric acid methyl ester

: 82948-88-7
5S,6R-DiHETE

Guidance literature:: With methanol; sodium hydroxide; at 20 ℃; for 1h;
DOI:10.1016/S0040-4039(01)80550-5

Reference yield:

: 79308-47-7,120400-95-5,127705-16-2
5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-5-hydroxy-pentanoic acid methyl ester

: 82948-88-7
5S,6R-DiHETE

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / 4.4 eq. anh. pyridine / CH₂Cl₂ / 2 h / 20 °C

2: 70 percent / THF-H₂O-TFA / 20 h / 20 °C

4: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 to 0 deg C, 3 h

5: 80 percent / MeOH/NaOH (10N) / 1 h / 20 °C

With tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; water; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4039(01)80550-5

Reference yield:

: 127705-13-9,127721-08-8
1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-butan-1-ol

: 82948-88-7
5S,6R-DiHETE

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / THF-H₂O-AcOH / 1 h / 20 °C

2: 70 percent / anh. K₂CO₃ / methanol / 1.5 h / 20 °C

3: 85 percent / 4.4 eq. anh. pyridine / CH₂Cl₂ / 2 h / 20 °C

4: 70 percent / THF-H₂O-TFA / 20 h / 20 °C

6: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 to 0 deg C, 3 h

7: 80 percent / MeOH/NaOH (10N) / 1 h / 20 °C

With tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; water; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(01)80550-5