4-Amino-5,6-dihydro-2H-pyridine-1,3-dicarboxylicacid1-tert-butylester3-ethylester

Base Information

• Chemical Name: 4-Amino-5,6-dihydro-2H-pyridine-1,3-dicarboxylicacid1-tert-butylester3-ethylester
• CAS No.: 947403-75-0
• Molecular Formula: C13H22N2O4
• Molecular Weight: 270.329
• Hs Code.: 2933399090
• Mol file: 947403-75-0.mol

Synonyms:QC-8460;4-amino-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester;

Chemical Property of 4-Amino-5,6-dihydro-2H-pyridine-1,3-dicarboxylicacid1-tert-butylester3-ethylester

Chemical Property:

• PSA: 81.86000
• LogP: 2.04130
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

1-tert-Butyl3-Ethyl4-Amino-5,6-dihydropyridine-1,3(2H)-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino-5,6-dihydro-2H-pyridine-1,3-dicarboxylicacid1-tert-butylester3-ethylester

There total 3 articles about 4-Amino-5,6-dihydro-2H-pyridine-1,3-dicarboxylicacid1-tert-butylester3-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate (98977-34-5) → 4-amino-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (947403-75-0)

Guidance literature:

With ammonium acetate; In ethanol; at 20 ℃; for 1h;

DOI:10.1021/acsmedchemlett.8b00531

Reference yield:

ethyl 4-piperidone-3-carboxylate hydrochloride (4644-61-5) → 4-amino-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (947403-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 h / 20 °C

2: ammonium hydroxide / water / 2.5 h / 80 °C

With ammonium hydroxide; triethylamine; In dichloromethane; water;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-amino-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (947403-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 h / 20 °C

2: ammonium hydroxide / water / 2.5 h / 80 °C

With ammonium hydroxide; triethylamine; In dichloromethane; water;

upstream raw materials:

1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate

ethyl 4-piperidone-3-carboxylate hydrochloride

di-tert-butyl dicarbonate

Downstream raw materials:

C₂₇H₃₃N₃O₄S

C₂₇H₃₃N₃O₅

tert-butyl 4-oxo-3-phenyl-2-thioxo-1,3,4, 5,7,8-hexahydropyrido[4,3-d]pyrimidine-6(2H)-carboxylate

ethyl 4-phenoxycarbonylamino-1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridine-3-carboxylate