2-(2-Fluorophenyl)-2-methylpropionicacid

Base Information

• Chemical Name: 2-(2-Fluorophenyl)-2-methylpropionicacid
• CAS No.: 870849-49-3
• Molecular Formula: C10H11FO2
• Molecular Weight: 182.195
• Hs Code.: 2916399090
• Mol file: 870849-49-3.mol

Synonyms:2-(2-Fluorophenyl)-2-methylpropionicacid;2-(2-Fluorophenyl)-2-methylpropanoic acid

Chemical Property of 2-(2-Fluorophenyl)-2-methylpropionicacid

Chemical Property:

• PSA: 37.30000
• LogP: 2.18790

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Fluorophenyl)-2-methylpropanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Fluorophenyl)-2-methylpropionicacid

There total 1 articles about 2-(2-Fluorophenyl)-2-methylpropionicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(2-fluorophenyl)-2-methylpropanoate (861901-19-1) → 2-methyl-2-(2-fluorophenyl)propanoic acid (870849-49-3)

Guidance literature:

methyl 2-(2-fluorophenyl)-2-methylpropanoate; With potassium hydroxide; ethanol; water; at 130 ℃; for 2h;

With hydrogenchloride; water; pH=1;

Reference yield:

2-methyl-2-(2-fluorophenyl)propanoic acid (870849-49-3) → C10H10ClFO (1017435-47-0)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In Isopropyl acetate; for 16.1667h;

Reference yield:

2-methyl-2-(2-fluorophenyl)propanoic acid (870849-49-3) → diethyl 2-(2-(2-fluorophenyl)-2-methylpropanoyl)malonate (1035261-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / Isopropyl acetate / 16.17 h

2.1: triethylamine; magnesium chloride / Isopropyl acetate / 3 h / 20 °C

2.2: 1.67 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; magnesium chloride; N,N-dimethyl-formamide; In Isopropyl acetate;

upstream raw materials:

methyl 2-(2-fluorophenyl)-2-methylpropanoate

Downstream raw materials:

C₁₀H₁₀ClFO

diethyl 2-(2-(2-fluorophenyl)-2-methylpropanoyl)malonate

Refernces

• 1、 -. "NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF". Page/Page column 108. . Retrieved 2008/12/06.