Chemical Property of N',N''-diacetylspermine
Chemical Property:
- PSA：82.26000
- LogP:3.16580
- Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
- Solubility.:DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
- Purity/Quality:
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97% *data from raw suppliers
N1,N12-DiacetylspermineDihydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
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- MSDS Files:
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Useful:
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Description
N1,N12-Acetylspermine is a diacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.
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Uses
N1,N12-Diacetylspermine Dihydrochloride is a diacetylated derivative of Spermine (S680510) and is recognized as a novel tumor marker in patients with breast and colorectal cancers.
