SRT3109

Base Information

• Chemical Name: SRT3109
• CAS No.: 1204707-71-0
• Molecular Formula: C18H23F2N5O4S2
• Molecular Weight: 475.541
• Mol file: 1204707-71-0.mol

Synonyms:SRT3109;N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R,3R)-3,4-dihydroxybutan-2-yl]amino]pyrimidin-4-yl]azetidine-1-sulfonamide;

Chemical Property of SRT3109

Chemical Property:

• PSA: 161.36000
• Density: 1.55
• LogP: 2.72780

Purity/Quality:

97% ^*data from raw suppliers

N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[[(1R,2R)-2,3-dihydroxy-1-methylpropyl]amino]-4-pyrimidinyl]-1-azetidinesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[[(1R,2R)-2,3-dihydroxy-1-methylpropyl]amino]-4-pyrimidinyl]-1-azetidinesulfonamide is a CXCR2 ligand and a potent chemoattractants for neutrophils.

Technology Process of SRT3109

There total 2 articles about SRT3109 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-[2-[(2,3-difluorobenzyl)thio]-6-({(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}amino)pyrimidin-4-yl]azetidine-1-sulfonamide (1204707-81-2) → N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(1R,2R)-2,3-dihydroxy-1-methyl-propyl]amino]pyrimidin-4-yl]azetidine-1-sulfonamide (1204707-71-0)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; water; at 60 ℃; for 20h; Product distribution / selectivity;

Reference yield: 63.0%

1-azetidine-1-sulfonamide (654073-32-2) + (2R,3R)-3-({6-chloro-2-[(2,3-difluorobenzyl)thio]pyrimidin-4-yl}amino)butane-1,2-diol (1204707-78-7) → N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(1R,2R)-2,3-dihydroxy-1-methyl-propyl]amino]pyrimidin-4-yl]azetidine-1-sulfonamide (1204707-71-0)

Guidance literature:

With caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; at 105 ℃; for 1.5h; Product distribution / selectivity; Inert atmosphere;

upstream raw materials:

1-azetidine-1-sulfonamide

(2R,3R)-3-({6-chloro-2-[(2,3-difluorobenzyl)thio]pyrimidin-4-yl}amino)butane-1,2-diol

N-[2-[(2,3-difluorobenzyl)thio]-6-({(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}amino)pyrimidin-4-yl]azetidine-1-sulfonamide