N-BOC-3-BROMOPYRROLIDINE

Base Information

Chemical Name:N-BOC-3-BROMOPYRROLIDINE
CAS No.:939793-16-5
Molecular Formula:C9H16BrNO2
Molecular Weight:250.136
Hs Code.:2933990090
Mol file:939793-16-5.mol

Synonyms:tert-butyl 3-bromopyrrolidine-1-carboxylate;

Suppliers and Price of N-BOC-3-BROMOPYRROLIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Boc-3-bromopyrrolidine
100mg
$ 45.00

TRC
N-Boc-3-bromopyrrolidine
250mg
$ 65.00

SynQuest Laboratories
1-Boc-3-Bromopyrrolidine
1 g
$ 77.00

SynQuest Laboratories
1-Boc-3-Bromopyrrolidine
5 g
$ 228.00

Sigma-Aldrich
1-Boc-3-bromopyrrolidine 96%
500mg
$ 104.00

Matrix Scientific
N-Boc-3-Bromopyrrolidine 95+%
1g
$ 347.00

Matrix Scientific
N-Boc-3-Bromopyrrolidine 95+%
10g
$ 425.00

Matrix Scientific
N-Boc-3-Bromopyrrolidine 95+%
5g
$ 899.00

J&W Pharmlab
3-Bromo-pyrrolidine-1-carboxylicacidtert-butylester 98%
25g
$ 500.00

J&W Pharmlab
3-Bromo-pyrrolidine-1-carboxylicacidtert-butylester 98%
1g
$ 50.00

Total 56 raw suppliers

Chemical Property of N-BOC-3-BROMOPYRROLIDINE

Chemical Property:

Melting Point:47-52℃
Boiling Point:277.5±33.0 °C(Predicted)
PKA:-3.30±0.40(Predicted)
Flash Point:>110°C
PSA：29.54000
Density:1.379±0.06 g/cm3(Predicted)
LogP:2.32860
Storage Temp.:2-8°C
Water Solubility.:Slightly soluble in water.

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-3-bromopyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,N
Hazard Codes:Xn,N
Statements: 22-36-50
Safety Statements: 26-61

MSDS Files:: SDS file from LookChem

Useful:

Uses (±)-1-Boc-3-bromopyrrolidine is used in organic synthesis.

Technology Process of N-BOC-3-BROMOPYRROLIDINE

There total 2 articles about N-BOC-3-BROMOPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 103057-44-9,83220-73-9
N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

: 939793-16-5,569660-97-5
3-bromopyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; Inert atmosphere;
DOI:10.1021/jacs.6b04610

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 939793-16-5,569660-97-5
3-bromopyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / neat (no solvent) / 20 °C

2: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 0 - 20 °C

With dmap; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; 2: |Appel Halogenation;
DOI:10.1021/acs.jmedchem.7b00316

Reference yield: 86.0%

: 939793-16-5,569660-97-5
3-bromopyrrolidine-1-carboxylic acid tert-butyl ester

: 5123-05-7
2-([1,1'-biphenyl]-4-yl)-5,5-dimethyl-1,3,2-dioxaborinane

: C₂₁H₂₅NO₂

Guidance literature:: With salicylidene-4-anisidine; potassium methanolate; cobalt(II) chloride; In N,N-dimethyl acetamide; at 60 ℃;
DOI:10.1021/acscatal.1c05586