8-Methoxy-1,7-naphthyridin-6-yl trifluoroMethanesulfonate

Base Information

• Chemical Name: 8-Methoxy-1,7-naphthyridin-6-yl trifluoroMethanesulfonate
• CAS No.: 207279-29-6
• Molecular Formula: C10H7F3N2O4S
• Molecular Weight: 308.238
• Mol file: 207279-29-6.mol

Synonyms:Methanesulfonic acid, trifluoro-, 8-methoxy-1,7-naphthyridin-6-yl ester

Chemical Property of 8-Methoxy-1,7-naphthyridin-6-yl trifluoroMethanesulfonate

Chemical Property:

• Melting Point: 99 - 101 °C
• PSA: 86.76000
• LogP: 2.94760

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Methoxy-1,7-naphthyridin-6-yl trifluoroMethanesulfonate

There total 2 articles about 8-Methoxy-1,7-naphthyridin-6-yl trifluoroMethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

trifluorormethanesulfonic acid (1493-13-6) + 8-methoxy-[1,7]naphthyridin-6-ylamine (55716-28-4) → 8-methoxy-1,7-naphthyridin-6-yl trifluoromethanesulfonate (207279-29-6)

Guidance literature:

With sodium nitrite; at 0 ℃; for 3h;

DOI:10.1016/S0960-894X(01)00720-X

Reference yield:

2-cyano-pyridin-3-yl-acetonitrile (5912-34-5) → 8-methoxy-1,7-naphthyridin-6-yl trifluoromethanesulfonate (207279-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Na / 16 h / 20 °C

2: 46 percent / aq. NaNO₂ / 3 h / 0 °C

With sodium; sodium nitrite;

DOI:10.1016/S0960-894X(01)00720-X

Reference yield: 75.0%

4-carboxyphenylboronic acid (14047-29-1) + 8-methoxy-1,7-naphthyridin-6-yl trifluoromethanesulfonate (207279-29-6) → 6-(4-carboxyphenyl)-8-methoxy-1,7-naphthyridine (207279-30-9)

Guidance literature:

With sodium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1016/S0960-894X(01)00720-X

upstream raw materials:

trifluorormethanesulfonic acid

8-methoxy-[1,7]naphthyridin-6-ylamine

2-cyano-pyridin-3-yl-acetonitrile

Downstream raw materials:

6-(4-carboxyphenyl)-8-methoxy-1,7-naphthyridine

6-(4-carboxyphenyl)-8-bromo-1,7-naphthyridine

RO-458,2640

N-(2-chloro-5-(8-methoxy-1,7-naphthyridin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide