1-Boc-4-aminoindazole

Base Information

• Chemical Name: 1-Boc-4-aminoindazole
• CAS No.: 801315-74-2
• Molecular Formula: C12H15N3O2
• Molecular Weight: 233.27
• Hs Code.: 2933990090
• Mol file: 801315-74-2.mol

Synonyms:tert-butyl 4-amino-1H-indazole-1-carboxylate;1H-INDAZOLE-1-CARBOXYLIC ACID,4-AMINO-,1,1-DIMETHYLETHYL ESTER-;

Chemical Property of 1-Boc-4-aminoindazole

Chemical Property:

• Vapor Pressure: 1.86E-06mmHg at 25°C
• Boiling Point: 395.3°C at 760 mmHg
• PKA: 2.62±0.10(Predicted)
• Flash Point: 192.8°C
• PSA: 70.14000
• Density: 1.24g/cm³
• LogP: 2.98290
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-Boc-1H-indazol-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-aminoindazole

There total 5 articles about 1-Boc-4-aminoindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl 4-nitro-1H-indazole-1-carboxylate (801315-75-3) → tert-butyl 4-amino-1H-indazole-1-carboxylate (801315-74-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; for 16h; under 1551.49 Torr; Inert atmosphere;

Reference yield:

nitro-4 indazole (2942-40-7) → tert-butyl 4-amino-1H-indazole-1-carboxylate (801315-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 12 h / 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 35 - 45 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; acetone;

DOI:10.14233/ajchem.2014.16794

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-amino-1H-indazole-1-carboxylate (801315-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 12 h / 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 35 - 45 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; acetone;

DOI:10.14233/ajchem.2014.16794

upstream raw materials:

tert-butyl 4-nitro-1H-indazole-1-carboxylate

di-tert-butyl dicarbonate

nitro-4 indazole

3-nitro-o-tolylamine

Refernces

• 1、 -. "AMIDE DERIVATIVES COMPRISING HETEROCYCLOALKYL RING". Paragraph 0259; 0260; 0263. . Retrieved 2020/05/20.
• 2、 -. "BENZOTHIADIAZINE COMPOUNDS". Page/Page column 292. . Retrieved 2017/07/23.