Ethyl 8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate

Base Information

Chemical Name:Ethyl 8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate
CAS No.:64761-20-2
Molecular Formula:C12H12N2O4
Molecular Weight:248.238
Hs Code.:2933990090
DSSTox Substance ID:DTXSID70497029
Wikidata:Q82346340
Mol file:64761-20-2.mol

Synonyms:64761-20-2;Ethyl 8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate;ETHYL 8-METHOXY-4-OXO-1H-1,5-NAPHTHYRIDINE-3-CARBOXYLATE;SCHEMBL13313440;DTXSID70497029;Ethyl8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate

Suppliers and Price of Ethyl 8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate 95+%
1g
$ 614.00

American Custom Chemicals Corporation
ETHYL-8-METHOXY-4-OXO-1,4-DIHYDRO-1,5-NAPHTHYRIDINE-3-CARBOXYLATE 95.00%
5MG
$ 497.05

Total 2 raw suppliers

Chemical Property of Ethyl 8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate

Chemical Property:

PSA：81.28000
LogP:1.10840
Storage Temp.:2-8°C
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:248.07970687
Heavy Atom Count:18
Complexity:380

Purity/Quality:

98% ^*data from raw suppliers

Ethyl8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CNC2=C(C=CN=C2C1=O)OC

Technology Process of Ethyl 8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate

There total 2 articles about Ethyl 8-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5435-54-1
4-hydroxy-3-nitropyridine

: 64761-20-2
8-methoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester

: 64761-17-7
5-methyl-4,8-dioxo-1,4,5,8-tetrahydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 0 °C / Inert atmosphere

2: hydrogenchloride; iron / methanol; water / Inert atmosphere

3: toluene / Reflux; Inert atmosphere

4: diphenylether / 0.42 h / Reflux; Inert atmosphere

With hydrogenchloride; iron; In methanol; diphenylether; water; toluene;
DOI:10.1039/c2ob25926e

Reference yield:

: 31872-62-5
4-methoxy-3-nitro-pyridine

: 64761-20-2
8-methoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester

: 64761-17-7
5-methyl-4,8-dioxo-1,4,5,8-tetrahydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; iron / methanol; water / Inert atmosphere

2: toluene / Reflux; Inert atmosphere

3: diphenylether / 0.42 h / Reflux; Inert atmosphere

With hydrogenchloride; iron; In methanol; diphenylether; water; toluene;
DOI:10.1039/c2ob25926e

Reference yield:

: 64761-20-2
8-methoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester

: 1393914-78-7
4,8-bis(4-(tert-butyl)phenyl)-1,5-naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide / Reflux; Inert atmosphere

2: quinoline / Reflux; Inert atmosphere

3: phosphorus(V) oxybromide / acetonitrile / 6 h / 80 - 170 °C / Inert atmosphere

4: palladium diacetate; potassium carbonate / water; N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

With quinoline; hydrogen bromide; palladium diacetate; potassium carbonate; phosphorus(V) oxybromide; In water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki coupling;
DOI:10.1039/c2ob25926e