3-(iodomethyl)oxetane

Base Information

• Chemical Name: 3-(iodomethyl)oxetane
• CAS No.: 1003013-77-1
• Molecular Formula: C4H7IO
• Molecular Weight: 198.003
• Hs Code.: 2932999099
• Mol file: 1003013-77-1.mol

Synonyms:3-(iodomethyl)oxetane

Chemical Property of 3-(iodomethyl)oxetane

Chemical Property:

• Boiling Point: 187.3±13.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.942±0.06 g/cm3(Predicted)
• LogP: 1.06780
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Iodomethyl)oxetane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(iodomethyl)oxetane

There total 2 articles about 3-(iodomethyl)oxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

→ 3-(iodomethyl)oxetane (1003013-77-1)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 0 - 25 ℃; for 18.5h;

Reference yield: 37.0%

3-hydroxylmethyl oxetane → 3-(iodomethyl)oxetane (1003013-77-1)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 0 - 25 ℃; for 1.5h;

Reference yield: 73.0%

3-(iodomethyl)oxetane (1003013-77-1) + (S)-methyl 2-(tert-butoxy)-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate → (S)-methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1-(oxetan-3-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

Guidance literature:

With tetrabutylammomium bromide; potassium iodide; In dichloromethane; at 40 ℃; for 18h;

Downstream raw materials:

2-(3-chloro-4-methylsulfanyl-phenyl)-3-oxetan-3-yl-propionic acid methyl ester

5-nitro-3-(oxetan-3-ylmethoxy)-1-tosyl-1H-pyrazolo[3,4-b]pyridine

Refernces

• 1、 -. "Pyrazole glucokinase activators". Page/Page column 82. . Retrieved 2008/06/13.