Morpholine, 2,6-dimethyl-, (2S,6S)-

Base Information

• Chemical Name: Morpholine, 2,6-dimethyl-, (2S,6S)-
• CAS No.: 276252-73-4
• Molecular Formula: C6H13NO
• Molecular Weight: 115.175
• Hs Code.: 2934999090
• Mol file: 276252-73-4.mol

Synonyms:trans-2,6-Dimethylmorpholin;S,S-2,6-dimethylmorpholine;Griseofulvic acid;Griseofulvinsaeure;O2'-Demethyl-griseofulvin;

Chemical Property of Morpholine, 2,6-dimethyl-, (2S,6S)-

Chemical Property:

• Boiling Point: 147℃
• PKA: 9.04±0.60(Predicted)
• Flash Point: 49℃
• PSA: 21.26000
• Density: 0.862
• LogP: 0.71200
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(2S,6S)-2,6-Dimethyl-morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Dimethyl-morpholine is used to synthesize BIRB 796 analogs for treatment of autoimmune diseases with p38α kinase-inhibiting activities. It is also used to synthesize chromium aminocarbene complexes of diterpenoids.

Technology Process of Morpholine, 2,6-dimethyl-, (2S,6S)-

There total 3 articles about Morpholine, 2,6-dimethyl-, (2S,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C6H13NO*C8H8O3 (943344-44-3) → MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) + (+/-)-trans-2,6-dimethylmorpholine (276252-73-4)

Guidance literature:

C₆H₁₃NO*C₈H₈O₃; With sodium hydroxide; In water; at 50 - 120 ℃; for 1 - 4h;

With hydrogenchloride; In water;

Reference yield: 80.0%

C6H11NO2 → cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8) + (+/-)-trans-2,6-dimethylmorpholine (276252-73-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1055/s-0034-1379641

Reference yield:

C6H12ClNO2 → cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8) + (+/-)-trans-2,6-dimethylmorpholine (276252-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 1 h / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1055/s-0034-1379641

upstream raw materials:

C₆H₁₃NO*C₈H₈O₃

Downstream raw materials:

(25,6R)-2,6-dimethyl-4-(5-nitropyridin-2-yl)morpholine

(2S,6R)-2,6-dimethyl-4-(5-aminopyridin-2-yl)morpholine

(R)-4-Amino-3-(4-chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-butan-1-one

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