Octahydro-pyrrolo[3,4-c]pyridine-2-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: Octahydro-pyrrolo[3,4-c]pyridine-2-carboxylic acid tert-butyl ester
• CAS No.: 885270-57-5
• Molecular Formula: C12H22N2O2
• Molecular Weight: 226.319
• Mol file: 885270-57-5.mol

Synonyms:OCTAHYDRO-PYRROLO[3,4-C]PYRIDINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER;

Chemical Property of Octahydro-pyrrolo[3,4-c]pyridine-2-carboxylic acid tert-butyl ester

Chemical Property:

• PSA: 41.57000
• LogP: 1.72950

Purity/Quality:

97% ^*data from raw suppliers

tert-Butylhexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Octahydro-pyrrolo[3,4-c]pyridine-2-carboxylic acid tert-butyl ester

There total 3 articles about Octahydro-pyrrolo[3,4-c]pyridine-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 6-oxohexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)carboxylate → hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylic acid tert-butyl ester (885270-57-5,236406-56-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -10 - 20 ℃; for 3h;

Reference yield:

tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (148404-28-8) → hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylic acid tert-butyl ester (885270-57-5,236406-56-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide; methanesulfonic acid / chloroform / 2 h / 70 °C

2: sodium hydride / tetrahydrofuran; water / 3 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -10 - 20 °C

With lithium aluminium tetrahydride; sodium azide; methanesulfonic acid; sodium hydride; In tetrahydrofuran; chloroform; water;

Reference yield:

hexahydro-1H-pyrrolo[3,4-c]pyridin-6(2H)one → hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylic acid tert-butyl ester (885270-57-5,236406-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; water / 3 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -10 - 20 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; water;

upstream raw materials:

tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

Downstream raw materials:

tert-butyl 5-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

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