tert-butyl 2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoate

Base Information

• Chemical Name: tert-butyl 2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoate
• CAS No.: 1022112-25-9
• Molecular Formula: C14H15F2NO5
• Molecular Weight: 315.269406
• Mol file: 1022112-25-9.mol

Synonyms:2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoic acid tert-butyl ester;

Chemical Property of tert-butyl 2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoate

Chemical Property:

• PSA: 89.19000
• LogP: 3.41050

Purity/Quality:

98%min ^*data from raw suppliers

TERT-BUTYL 2-(2,3-DIFLUORO-6-NITROPHENYL)-3-OXOBUTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoate

There total 1 articles about tert-butyl 2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl acetoacetate (1694-31-1) + 2,3,4-trifluoronitrobenzene (771-69-7) → tert-butyl 2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoate (1022112-25-9)

Guidance literature:

tert-butyl acetoacetate; With sodium tert-pentoxide; In toluene; at 40 ℃;

2,3,4-trifluoronitrobenzene; In toluene; at 70 ℃; for 3h;

With sulfuric acid; In water; toluene; at 25 ℃; pH=1; Product distribution / selectivity;

Reference yield:

tert-butyl 2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoate (1022112-25-9) → tert-butyl 2-(2-fluoro-3-hydroxy-6-nitrophenyl)-3-oxobutanoate (1022112-27-1)

Guidance literature:

tert-butyl 2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoate; With N-benzyl-trimethylammonium hydroxide; In water; toluene;

With sodium hydroxide; In water; at 50 ℃; for 18h;

With sulfuric acid; In water; at 25 ℃; Product distribution / selectivity;

upstream raw materials:

tert-butyl acetoacetate

2,3,4-trifluoronitrobenzene

Downstream raw materials:

tert-butyl 2-(2-fluoro-3-hydroxy-6-nitrophenyl)-3-oxobutanoate

Refernces