(2-AMINO-5-METHOXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (2-AMINO-5-METHOXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 362670-09-5
• Molecular Formula: C12H18N2O3
• Molecular Weight: 238.287
• Hs Code.: 2924299090
• Mol file: 362670-09-5.mol

Synonyms:Carbamic acid, (2-amino-5-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI);

Chemical Property of (2-AMINO-5-METHOXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 317.6±32.0 °C(Predicted)
• PKA: 13.01±0.70(Predicted)
• PSA: 77.07000
• Density: 1.163±0.06 g/cm3(Predicted)
• LogP: 3.21920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

N1-Boc-5-methoxy-1,2-benzenediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-AMINO-5-METHOXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

There total 1 articles about (2-AMINO-5-METHOXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester (185428-55-1) → (2-amino-5-methoxyphenyl)carbamate tert-butyl ester (362670-09-5)

Guidance literature:

palladium-carbon;

Reference yield: 70.1%

(2-amino-5-methoxyphenyl)carbamate tert-butyl ester (362670-09-5) + C17H14N4O3 → 3-((4-((2-amino-4-methoxyphenyl)aminocarbonyl)benzyl)amino)quinoxaline-6-carboxamide

Guidance literature:

(2-amino-5-methoxyphenyl)carbamate tert-butyl ester; C₁₇H₁₄N₄O₃; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With hydrogenchloride; In water; for 1h;

Reference yield: 63.9%

(2-amino-5-methoxyphenyl)carbamate tert-butyl ester (362670-09-5) + C18H15N3O3 → 2-((4-((2-amino-4-methoxyphenyl)aminocarbonyl)benzyl)amino)quinoline-7-carboxamide

Guidance literature:

(2-amino-5-methoxyphenyl)carbamate tert-butyl ester; C₁₈H₁₅N₃O₃; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With hydrogenchloride; In water; for 1h;

upstream raw materials:

(5-methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester

Downstream raw materials:

{5-methoxy-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester

7-methoxy-4-phenylimidazo[1,5-a]quinoxaline

7-methoxy-3-phenyl-4-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]quinoxaline

7-methoxy-4-(4-methoxyphenyl)-3-phenylimidazo[1,5-a]quinoxaline