3-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid

Base Information

Chemical Name:3-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid
CAS No.:683219-25-2
Molecular Formula:C₁₅H₁₈F₃NO₄
Molecular Weight:333.307
Hs Code.:
Mol file:683219-25-2.mol

Synonyms:BOC-DL-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID;

Suppliers and Price of 3-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
Boc-3-Trifluoromethyl-DL-b-phenylalanine 97%
5g
$ 330.00

Total 9 raw suppliers

Chemical Property of 3-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid

Chemical Property:

PSA：75.63000
LogP:4.13680

Purity/Quality:

97% ^*data from raw suppliers

Boc-3-Trifluoromethyl-DL-b-phenylalanine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid

There total 2 articles about 3-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 143438-91-9,793663-51-1
3-amino-3-(3-(trifluoromethyl)phenyl)propanoic acid

: 501015-18-5,683219-25-2
3-{[(tert-butoxy)carbonyl]amino}-3-[3-(trifluoromethyl)phenyl]propanoic acid

Guidance literature:: With sodium hydroxide; In tert-butyl alcohol; at 0 - 20 ℃; for 18h;

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 501015-18-5,683219-25-2
3-{[(tert-butoxy)carbonyl]amino}-3-[3-(trifluoromethyl)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate / ethanol / 12 h / Reflux

2: sodium hydroxide / tert-butyl alcohol / 18 h / 0 - 20 °C

With ammonium formate; sodium hydroxide; In ethanol; tert-butyl alcohol;

Reference yield:

: 501015-18-5,683219-25-2
3-{[(tert-butoxy)carbonyl]amino}-3-[3-(trifluoromethyl)phenyl]propanoic acid

: methyl (2S)-2-{3-amino-3-[3-(trifluoromethyl)phenyl]propanamido}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 12 h / -5 - 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;