2',4'-Dichloro-2-imidazole acetophenone

Base Information

• Chemical Name: 2',4'-Dichloro-2-imidazole acetophenone
• CAS No.: 252950-14-4
• Molecular Formula: C11H8Cl2N2O
• Molecular Weight: 255.103
• Mol file: 252950-14-4.mol

Synonyms:2,4-Dichloro-2-imidazole acetophenone;1-(2,4-Dichlorophenyl)-2-(1H-iMidazol-2-yl)ethanone

Chemical Property of 2',4'-Dichloro-2-imidazole acetophenone

Chemical Property:

• Boiling Point: 480.3±35.0 °C(Predicted)
• PKA: 13.04±0.10(Predicted)
• PSA: 45.75000
• Density: 1.440±0.06 g/cm3(Predicted)
• LogP: 3.14190
• Solubility.: Methanol

Purity/Quality:

97% ^*data from raw suppliers

2'',4''-Dichloro-2-imidazoleAcetophenone ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4'-Dichloro-2-imidazole acetophenone

There total 6 articles about 2',4'-Dichloro-2-imidazole acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1H-imidazole (288-32-4) + 2,2',4'-trichloroacetophenone (4252-78-2) → 1-(2,4-dichlorophenyl)-2-imidazolylethan-1-one (252950-14-4)

Guidance literature:

In acetonitrile;

Reference yield: 56.0%

ethyl 5-(2,4-dichlorophenyl)-4-imidazolyl-5-oxopentanoate + 2,4-dichlorobenzoyl chloride (89-75-8) → 1-(2,4-dichlorophenyl)-2-imidazolylethan-1-one (252950-14-4)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; benzene;

Reference yield:

1H-imidazole (288-32-4) + 2,2',4'-trichloroacetophenone (4252-78-2) → 1-(2,4-dichlorophenyl)-2-imidazolylethan-1-one (252950-14-4) + N-[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]-N'-(5-nitropyridin-2-yl)ethane-1,2-diamine

Guidance literature:

In dichloromethane; toluene;

upstream raw materials:

1H-imidazole

2,2',4'-trichloroacetophenone

2,4-dichlorobenzoyl chloride

Downstream raw materials:

(2Z)-1-(2,4-dichlorophenyl)-3-(dimethylamino)-2-imidazol-2-ylprop-2-en-1-one

[4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl](2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl) amine

CHIR 98014

6-{2-[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino}nicotinonitrile