S6K-18

Base Information

Chemical Name:S6K-18
CAS No.:1265789-88-5
Molecular Formula:C17H18N4O3S
Molecular Weight:358.41
Hs Code.:
Mol file:1265789-88-5.mol

Synonyms:S6K-18;CS-2668;S6K-18 >=95%;2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-carboxylic acid;3-Thiophenecarboxylic acid, 5-(1,1-dimethylethyl)-2-[[(1H-indazol-5-ylamino)carbonyl]amino]-

Suppliers and Price of S6K-18

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-carboxylicacid 97%
10g
$ 8100.00

Matrix Scientific
2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-carboxylicacid 97%
5g
$ 4500.00

DC Chemicals
S6K-18 >98%
50 mg
$ 450.00

DC Chemicals
S6K-18 >98%
250 mg
$ 1500.00

AK Scientific
S6K-18
10mg
$ 560.00

Adipogen Life Sciences
S6K-18 ≥95%
100 mg
$ 2317.00

Total 9 raw suppliers

Chemical Property of S6K-18

Chemical Property:

PSA：135.35000
LogP:4.41010
Storage Temp.:Refrigerator, Under inert atmosphere
Solubility.:Aqueous Base (Slightly, Heated), DMSO (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-carboxylic Acid can be used as potent and selective thiophene urea-templated inhibitors of S6K.

Technology Process of S6K-18

There total 3 articles about S6K-18 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890664-87-6
6-tert-butyl-1H-thieno[2,3-d][1,3]oxazine-2,4-dione

: 19335-11-6
1H-indazol-5-ylamine

: 1265789-88-5
2-(3-(1H-indazol-5-yl)ureido)-5-tert-butylthiophene-3-carboxylic acid

Guidance literature:: With triethylamine; In acetonitrile; at 100 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.bmcl.2010.11.069

Reference yield:

: 216574-71-9
2-amino-5-tert-butylthiophene-3-carboxylic acid methyl ester

: 1265789-88-5
2-(3-(1H-indazol-5-yl)ureido)-5-tert-butylthiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / 0.5 h / 150 °C / Microwave irradiation

1.2: 2 h / 20 °C

2.1: triethylamine / acetonitrile / 0.5 h / 100 °C / Microwave irradiation

With water; triethylamine; sodium hydroxide; In acetonitrile;
DOI:10.1016/j.bmcl.2010.11.069

Reference yield:

: 2987-16-8
3,3-dimethylbutyrylaldehyde

: 1265789-88-5
2-(3-(1H-indazol-5-yl)ureido)-5-tert-butylthiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfur; triethylamine / N,N-dimethyl-formamide / 20 - 50 °C

2.1: water; sodium hydroxide / 0.5 h / 150 °C / Microwave irradiation

2.2: 2 h / 20 °C

3.1: triethylamine / acetonitrile / 0.5 h / 100 °C / Microwave irradiation

With water; sulfur; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide; acetonitrile; 1.1: Gewald reaction;
DOI:10.1016/j.bmcl.2010.11.069