(2S,5S)-2,5-Dimethylmorpholine

Base Information

• Chemical Name: (2S,5S)-2,5-Dimethylmorpholine
• CAS No.: 1258277-12-1
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Mol file: 1258277-12-1.mol

Synonyms:Morpholine, 2,5-dimethyl-, (2S,5S)-;

Chemical Property of (2S,5S)-2,5-Dimethylmorpholine

Chemical Property:

• Boiling Point: 151℃
• PKA: 9.07±0.60(Predicted)
• Flash Point: 50℃
• PSA: 21.26000
• Density: 0.862
• LogP: 0.71200

Purity/Quality:

97% ^*data from raw suppliers

(2S,5S)-2,5-Dimethylmorpholine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5S)-2,5-Dimethylmorpholine

There total 14 articles about (2S,5S)-2,5-Dimethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2S,5S)-2,5-Dimethyl-3-oxoperhydro-1,4-oxazin (115206-98-9) → (2S,5S)-2,5-dimethylmorpholine (106-56-9,67804-27-7,68043-56-1,1639924-58-5,1258277-12-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1055/s-0034-1379641

Reference yield: 80.0%

C6H11NO2 → (2R,5R)-2,5-dimethylmorpholine (1130061-44-7,1639924-58-5,1258277-12-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1055/s-0034-1379641

Reference yield:

diisopropanolamine (110-97-4,1335-54-2) → trans-2,5-dimethylmorpholine (1639924-58-5,1258277-12-1) + (.+-.)-trans-2,6-dimethyl-morpholine (141-91-3,6485-45-6,6485-55-8) + cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8)

Guidance literature:

With sulfuric acid; In water; at 178 - 183 ℃; Overall yield = 83.63 percent; Overall yield = 308.2 g;

upstream raw materials:

(β-hydroxy-isopropyl)-(2-hydroxy-propyl)-amine

Dipropylene glycol

(2R,5R)-benzyl 2,5-dimethylmorpholine-4-carboxylate

(2S,5S)-2,5-Dimethyl-3-oxoperhydro-1,4-oxazin