1,6-Diaza-spiro[3.4]octane-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 1,6-Diaza-spiro[3.4]octane-1-carboxylic acid tert-butyl ester
• CAS No.: 1148044-31-8
• Molecular Formula: C₁₁H₂₀N₂O₂
• Molecular Weight: 212.292
• Hs Code.: 2933990090
• Mol file: 1148044-31-8.mol

Synonyms:1,6-Diaza-spiro[3.4]octane-1-carboxylic acid tert-butyl ester;1-N-Boc-1,6-diaza-spiro[3.4]octane;1,6-Diazaspiro[3.4]octane-1-carboxylic acid, 1,1-diMethylethyl ester

Chemical Property of 1,6-Diaza-spiro[3.4]octane-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 301.3±15.0 °C(Predicted)
• PKA: 10.54±0.20(Predicted)
• PSA: 41.57000
• Density: 1.10±0.1 g/cm3 (20 oC 760 Torr)
• LogP: 1.62600
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl1,6-Diazaspiro[3.4]octane-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 1,6-Diazaspiro[3.4]octane-1-carboxylate is a reactant in the preparation of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.

Technology Process of 1,6-Diaza-spiro[3.4]octane-1-carboxylic acid tert-butyl ester

There total 1 articles about 1,6-Diaza-spiro[3.4]octane-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C18H26N2O2 (1148044-30-7) → tert-butyl 1,6-diazaspiro[3.4]octane-1-carboxylate (1148044-31-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol;

DOI:10.1016/j.bmcl.2009.01.099

Reference yield:

2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid (956317-36-5) + tert-butyl 1,6-diazaspiro[3.4]octane-1-carboxylate (1148044-31-8) → C21H27N5O3

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 17h;

DOI:10.1002/cmdc.201600175

Reference yield:

tert-butyl 1,6-diazaspiro[3.4]octane-1-carboxylate (1148044-31-8) → (6-(5-chlorobenzo[d]oxazol-2-yl)-1,6-diazaspiro[3.4]octan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 60 °C

2: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 17 h / 20 °C

With hydrogenchloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/cmdc.201600175

upstream raw materials:

C₁₈H₂₆N₂O₂

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