4-(4-trifluoroMethoxy phenoxy)benzoic acid

Base Information

• Chemical Name: 4-(4-trifluoroMethoxy phenoxy)benzoic acid
• CAS No.: 617245-31-5
• Molecular Formula: C14H9F3O4
• Molecular Weight: 298.21
• Mol file: 617245-31-5.mol

Synonyms:4-(4-trifluoroMethoxy phenoxy)benzoic acid;

Chemical Property of 4-(4-trifluoroMethoxy phenoxy)benzoic acid

Chemical Property:

• PSA: 55.76000
• LogP: 4.07570

Purity/Quality:

≥99% ^*data from raw suppliers

4-(4-(Trifluoromethoxy)phenoxy)benzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-trifluoroMethoxy phenoxy)benzoic acid

There total 8 articles about 4-(4-trifluoroMethoxy phenoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(4-(trifluoromethoxy)phenoxy)benzonitrile (1258834-97-7) → 4-(4-(trifluoromethoxy)phenoxy)benzoic acid (617245-31-5)

Guidance literature:

With dihydrogen peroxide; potassium hydroxide; In methanol; ethanol; for 4h; Reflux;

DOI:10.1016/j.ejmech.2013.09.008

Reference yield: 89.0%

C15H11F3O4 → 4-(4-(trifluoromethoxy)phenoxy)benzoic acid (617245-31-5)

Guidance literature:

With sodium hydroxide; In ethanol; at 80 ℃; for 3h; Reflux;

DOI:10.1016/j.cclet.2015.06.017

Reference yield:

C16H13F3O4 → 4-(4-(trifluoromethoxy)phenoxy)benzoic acid (617245-31-5)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 80 ℃; for 1h;

DOI:10.1007/s12272-018-1050-2

upstream raw materials:

4-(4-(trifluoromethoxy)phenoxy)benzonitrile

4-fluorobenzonitrile

4-(trifluoromethoxy)aniline

1-iodo-4-(trifluoromethoxy)benzene

Refernces

• 1、 Sun, Chi-Yu,Li, Yang-Sheng,Shi, Ai-Long,Li, Ya-Fei,Cao, Rui-Fang,Ding, Huai-Wei,Yin, Qing-Qing,Zhang, Li-Juan,Zheng, Hua-Chuan,Song, Hong-Rui. "Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives". supporting information. p. 1307 - 1310. Retrieved 2015/12/31.