1-ISOBUTYRYLPIPERIDIN-4-AMINE

Base Information

• Chemical Name: 1-ISOBUTYRYLPIPERIDIN-4-AMINE
• CAS No.: 172478-05-6
• Molecular Formula: C₉H₁₈N₂O
• Molecular Weight: 170.255
• Hs Code.: 2933399090
• Mol file: 172478-05-6.mol

Synonyms:1-propanone, 1-(4-amino-1-piperidinyl)-2-methyl-; 1-(4-aminopiperidin-1-yl)-2-methylpropan-1-one

Chemical Property of 1-ISOBUTYRYLPIPERIDIN-4-AMINE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 295.534°C at 760 mmHg
• Flash Point: 132.535°C
• PSA: 46.33000
• Density: 1.003g/cm³
• LogP: 1.23030

Purity/Quality:

99% ^*data from raw suppliers

1-ISOBUTYRYLPIPERIDIN-4-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-ISOBUTYRYLPIPERIDIN-4-AMINE

There total 5 articles about 1-ISOBUTYRYLPIPERIDIN-4-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-<(t-butyloxycarbonyl)methylamino>-1-propionyl-piperidine (172478-03-4) → 3-methylamino-1-propionyl-piperidine (172478-05-6)

Guidance literature:

With hydrogenchloride; In diethyl ether; Ambient temperature;

DOI:10.1016/0040-4020(95)00716-L

Reference yield:

1-benzyl-3-piperidone (40114-49-6) → 3-methylamino-1-propionyl-piperidine (172478-05-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 71 percent / NaBH₄ / methanol; H₂O / 1 h / Ambient temperature

2: 85 percent / CH₂Cl₂

3: 90 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

4: 80 percent / 1 h / 100 °C

5: 87 percent / HCl / diethyl ether / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1016/0040-4020(95)00716-L

Reference yield:

1-benzyl-N-methylpiperidin-3-amine (60717-45-5) → 3-methylamino-1-propionyl-piperidine (172478-05-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / CH₂Cl₂

2: 90 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

3: 80 percent / 1 h / 100 °C

4: 87 percent / HCl / diethyl ether / Ambient temperature

With hydrogenchloride; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;

DOI:10.1016/0040-4020(95)00716-L

upstream raw materials:

3-<(t-butyloxycarbonyl)methylamino>-1-propionyl-piperidine

1-benzyl-3-piperidone

1-benzyl-N-methylpiperidin-3-amine

3-<(t-butyloxycarbonyl)methylamino>-piperidine

Refernces