4-(2,2,2-TRIFLUOROETHOXY)PHENYLBORONIC ACID

Base Information

• Chemical Name: 4-(2,2,2-TRIFLUOROETHOXY)PHENYLBORONIC ACID
• CAS No.: 886536-37-4
• Molecular Formula: C8H8BF3O3
• Molecular Weight: 219.956
• Hs Code.: 2931900090
• Mol file: 886536-37-4.mol

Synonyms:4-(2,2,2-TRIFLUOROETHOXY)PHENYLBORONIC ACID;4-(2,2,2-Trifluoroethoxy)benzeneboronic acid;4-(2,2,2-Trifluoroethoxy)benzeneboronic acid 98%;4-(2,2,2-Trifluoroethoxy)benzeneboronicacid98%

Chemical Property of 4-(2,2,2-TRIFLUOROETHOXY)PHENYLBORONIC ACID

Chemical Property:

• Vapor Pressure: 0.000618mmHg at 25°C
• Melting Point: 191-194℃
• Boiling Point: 297.1°C at 760 mmHg
• PKA: 8.58±0.16(Predicted)
• Flash Point: 133.5°C
• PSA: 49.69000
• Density: 1.35g/cm³
• LogP: 0.30750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-(2,2,2-Trifluoroethoxy)phenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(2,2,2-Trifluoroethoxy)phenylboronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of 4-(2,2,2-TRIFLUOROETHOXY)PHENYLBORONIC ACID

There total 1 articles about 4-(2,2,2-TRIFLUOROETHOXY)PHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ (4-(2,2,2-trifluoroethoxy)phenyl)boronic acid (886536-37-4)

Guidance literature:

With isopropylmagnesium chloride; In 2-methyltetrahydrofuran; at -15 - -10 ℃; for 1h; Inert atmosphere;

Reference yield: 87.3%

(4-(2,2,2-trifluoroethoxy)phenyl)boronic acid (886536-37-4) + L-Tartaric acid (87-69-4,138508-61-9) + 3-amino-1-(5-bromopyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoropropan-2-ol → 3-amino-2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol L-tartaric acid salt

Guidance literature:

(4-(2,2,2-trifluoroethoxy)phenyl)boronic acid; 3-amino-1-(5-bromopyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoropropan-2-ol; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In water; iso-butanol; at 85 ℃; Inert atmosphere;

L-Tartaric acid; at 70 - 75 ℃;

Reference yield: 84.2%

(4-(2,2,2-trifluoroethoxy)phenyl)boronic acid (886536-37-4) + 2-(3-bromo-6-oxopyridazin-1(6H)-yl)-N-ethylacetamide → N-ethyl-2-(6-oxo-3-(4-(2,2,2-trifluoroethoxy)phenyl)pyridazin-1(6H)-yl)acetamide

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 3h; Inert atmosphere;

Downstream raw materials:

C₂₂H₁₄F₇NO₂

Refernces

• 1、 -. "Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them". Page/Page column 24. . Retrieved 2010/11/30.