tert-Butyl 2-(chloromethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 2-(chloromethyl)pyrrolidine-1-carboxylate
CAS No.:1142400-61-0
Molecular Formula:C10H18ClNO2
Molecular Weight:220
Hs Code.:2933990090
DSSTox Substance ID:DTXSID00590991
Nikkaji Number:J3.195.042B
Mol file:1142400-61-0.mol

Synonyms:1142400-61-0;1-Boc-2-Chloromethylpyrrolidine;tert-Butyl 2-(chloromethyl)pyrrolidine-1-carboxylate;2-Chloromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;1-Boc-2-Chloromethyl-pyrrolidine;2-Chloromethylpyrrolidine-1-carboxylic acid tert-butyl ester;SCHEMBL20893390;DTXSID00590991;1-Boc-2-(chloromethyl)pyrrolidine;1-Pyrrolidinecarboxylic acid, 2-(chloromethyl)-, 1,1-dimethylethyl ester;AKOS015906935;AM90690;SB19926;SB37063;DA-17203;CS-0272848;F83452;EN300-1880311;A894224

Suppliers and Price of tert-Butyl 2-(chloromethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-Boc-2-Chloromethylpyrrolidine 95+%
5g
$ 852.00

Chemenu
tert-Butyl2-(chloromethyl)pyrrolidine-1-carboxylate 95%
5g
$ 797.00

American Custom Chemicals Corporation
2-CHLOROMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00%
5MG
$ 500.48

Alichem
1-Boc-2-Chloromethylpyrrolidine
5g
$ 937.20

Total 10 raw suppliers

Chemical Property of tert-Butyl 2-(chloromethyl)pyrrolidine-1-carboxylate

Chemical Property:

Boiling Point:284℃
PKA:-2.38±0.40(Predicted)
Flash Point:126℃
PSA：29.54000
Density:1.101
LogP:2.56260
Storage Temp.:2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:219.1026065
Heavy Atom Count:14
Complexity:213

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-2-Chloromethylpyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCCC1CCl

Technology Process of tert-Butyl 2-(chloromethyl)pyrrolidine-1-carboxylate

There total 4 articles about tert-Butyl 2-(chloromethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1142400-61-0,403735-05-7
2-chloromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With 1,3,5-trichloro-2,4,6-triazine; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane; at 25 ℃; for 0.666667h;
DOI:10.1021/ol017168p

Reference yield: 80.0%

: 59378-81-3,69610-40-8,83435-58-9
1-(tert-butoxycarbonyl)prolin-2R-ol

: 210963-90-9,1142400-61-0,403735-05-7
1-t-butoxycarbonyl-(2R)-2-chloromethylpyrrolidine

Guidance literature:: With tetrachloromethane; PS-triphenylphosphine; In dichloromethane; for 12h; Heating;
DOI:10.1016/S0040-4039(03)01117-1

Reference yield: 70.0%

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 128542-75-6
(S)-2-(bromomethyl)-1-<(tert-butyloxy)carbonyl>pyrrolidine

: 1142400-61-0,403735-05-7
2-chloromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide; sodium bromide; In dichloromethane; at 25 ℃; for 0.666667h;
DOI:10.1021/ol017168p