AMG 458

Base Information

• Chemical Name: AMG 458
• CAS No.: 913376-83-7
• Molecular Formula: C₃₀H₂₉N₅O₅
• Molecular Weight: 539.591
• Mol file: 913376-83-7.mol

Synonyms:AMG458;AMG-458,AMG458;Substituted Pyrazolone,17;UNII-4535RW5Y3A;

Chemical Property of AMG 458

Chemical Property:

• PSA: 123.99000
• Density: 1.339
• LogP: 5.09870
• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

AMG-458 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: AMG-458 is a potent inhibitor of c-Met with an IC50 of 60 nM.

Technology Process of AMG 458

There total 2 articles about AMG 458 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

5-(7-methoxyquinolin-4-yloxy)pyridin-2-amine (913375-96-9) + 1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (913376-56-4) → AMG 458 (913376-83-7)

Guidance literature:

1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 40 ℃; for 0.25h;

5-(7-methoxyquinolin-4-yloxy)pyridin-2-amine; In N,N-dimethyl-formamide; at 60 ℃; for 18h;

DOI:10.1021/jm800401t

Reference yield:

→ AMG 458 (913376-83-7)

Guidance literature:

upstream raw materials:

5-(7-methoxyquinolin-4-yloxy)pyridin-2-amine

1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid