2-(4-FLUORO-PHENYL)-5-HYDROXY-BENZOFURAN-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

Chemical Name:2-(4-FLUORO-PHENYL)-5-HYDROXY-BENZOFURAN-3-CARBOXYLIC ACID ETHYL ESTER
CAS No.:691856-86-7
Molecular Formula:C17H13FO4
Molecular Weight:300.286
Hs Code.:
Mol file:691856-86-7.mol

Synonyms:BMS-929-2;ethyl 2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate;2-(4-fluorophenyl)-5-hydroxy-3-BenzofuranCarbocylic acid ethyl ester;2-(4-FLUORO-PHENYL)-5-HYDROXY-BENZOFURAN-3-CARBOXYLIC ACID ETHYL ESTER;3-Benzofurancarboxylic acid, 2-(4-fluorophenyl)-5-hydroxy-, ethyl ester

Suppliers and Price of 2-(4-FLUORO-PHENYL)-5-HYDROXY-BENZOFURAN-3-CARBOXYLIC ACID ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate 95+%
1g
$ 489.00

ChemScene
3-Benzofurancarboxylicacid,2-(4-fluorophenyl)-5-hydroxy-,ethylester
100mg
$ 605.00

Alichem
Ethyl2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate
1g
$ 521.00

Alichem
Ethyl2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate
250mg
$ 224.64

Total 8 raw suppliers

Chemical Property of 2-(4-FLUORO-PHENYL)-5-HYDROXY-BENZOFURAN-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

Boiling Point:468.6±45.0 °C(Predicted)
PKA:8.28±0.40(Predicted)
Density:1.313±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUORO-PHENYL)-5-HYDROXY-BENZOFURAN-3-CARBOXYLIC ACID ETHYL ESTER

There total 3 articles about 2-(4-FLUORO-PHENYL)-5-HYDROXY-BENZOFURAN-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 106-51-4
p-benzoquinone

: 691856-86-7
ethyl 2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); In toluene; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.7b01319

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 691856-86-7
ethyl 2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / toluene / 1 h / 80 °C

1.2: 18 h / 20 - 70 °C

2.1: zinc(II) chloride / toluene; diethyl ether; tetrahydrofuran / 6 h / 110 °C

With potassium tert-butylate; zinc(II) chloride; In tetrahydrofuran; diethyl ether; toluene;

Reference yield:

: 456-22-4
4-Fluorobenzoic acid

: 691856-86-7
ethyl 2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium chloride / tetrahydrofuran / 18 h / 25 - 65 °C / Inert atmosphere

1.2: 12 h / 25 - 30 °C / Inert atmosphere

2.1: zinc(II) chloride / toluene / 12.5 h / 25 - 120 °C / Inert atmosphere

With magnesium chloride; zinc(II) chloride; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2018.01.029