N-(Piperidin-4-yl)pyrimidin-2-amine hydrochloride

Base Information

• Chemical Name: N-(Piperidin-4-yl)pyrimidin-2-amine hydrochloride
• CAS No.: 950649-10-2
• Molecular Formula: C₉H₁₄N₄*ClH
• Molecular Weight: 214.698
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00599444
• Mol file: 950649-10-2.mol

Synonyms:950649-10-2;N-(Piperidin-4-yl)pyrimidin-2-amine hydrochloride;Piperidin-4-yl-pyrimidin-2-yl-amine hydrochloride;N-piperidin-4-ylpyrimidin-2-amine;hydrochloride;SCHEMBL4114881;DTXSID00599444;AOQWLUWWMVCOIE-UHFFFAOYSA-N;MFCD08752676;ZB1746;AKOS015940882;piperidin-4-ylpyrimidin-2-ylamine hcl;DS-2534;N-(4-Piperidinyl)-2-Pyrimidinamine HCl;DB-080175;2-(4-piperidylamino)pyrimidine hydrochloride;CS-0040211;PIPERIDIN-4-YL-PYRIMIDIN-2-YL-AMINEHCL;S10802;4-(Pyrimidin-2-ylamino)-piperidine Hydrochloride;N-(Piperidin-4-yl)pyrimidin-2-aminehydrochloride;A859211;PIPERIDIN-4-YL-PYRIMIDIN-2-YL-AMINEHYDROCHLORIDE;N-(Piperidin-4-yl)pyrimidin-2-amine--hydrogen chloride (1/1)

Chemical Property of N-(Piperidin-4-yl)pyrimidin-2-amine hydrochloride

Chemical Property:

• PSA: 49.84000
• LogP: 1.84430
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 214.0985242
• Heavy Atom Count: 14
• Complexity: 139

Purity/Quality:

97% ^*data from raw suppliers

N-(Piperidin-4-yl)pyrimidin-2-aminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1NC2=NC=CC=N2.Cl

Technology Process of N-(Piperidin-4-yl)pyrimidin-2-amine hydrochloride

There total 2 articles about N-(Piperidin-4-yl)pyrimidin-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(pyrimidin-2-ylamino)piperidine-1-carboxylate (301225-40-1) → 4-(pyrimidin-2-ylamino)-piperidine hydrochloride (950649-10-2,63260-58-2)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 96h;

Reference yield:

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → 4-(pyrimidin-2-ylamino)-piperidine hydrochloride (950649-10-2,63260-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 48 h / Heating / reflux

2: hydrogenchloride; water / 1,4-dioxane / 96 h / 20 °C

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; isopropyl alcohol;

upstream raw materials:

tert-butyl 4-(pyrimidin-2-ylamino)piperidine-1-carboxylate

1-(tert-butoxycarbonyl)-4-aminopiperidine