3,3-DIFLUOROCYCLOPENTANAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 3,3-DIFLUOROCYCLOPENTANAMINE HYDROCHLORIDE
• CAS No.: 939525-61-8
• Molecular Formula: C5H10ClF2N
• Molecular Weight: 157.5894064
• Hs Code.: 2921300090
• Mol file: 939525-61-8.mol

Synonyms:3,3-difluorocyclopentanaM...;3,3-Difluorocyclopentanamine;3,3-DIFLUOROCYCLOPENTANAMINE HYDROCHLORIDE;

Chemical Property of 3,3-DIFLUOROCYCLOPENTANAMINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 113℃
• PKA: 9.13±0.40(Predicted)
• Flash Point: 16℃
• PSA: 26.02000
• Density: 1.12
• LogP: 1.83320

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,3-difluorocyclopentanamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,3-Difluorocyclopentanamine is used as a reactant in the preparation of novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Technology Process of 3,3-DIFLUOROCYCLOPENTANAMINE HYDROCHLORIDE

There total 3 articles about 3,3-DIFLUOROCYCLOPENTANAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 3,3-difluorocyclopentylcarbamate (939385-02-1) → 3,3-difluorocyclopentanamine (939525-61-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield:

[cis-(+/-)]-(3-hydroxycyclopentyl)carbamic acid phenylmethyl ester (939426-84-3) → 3,3-difluorocyclopentanamine (939525-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

2: diethylamino-sulfur trifluoride / chloroform / 3 h / 0 - 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; pyridinium chlorochromate; In methanol; dichloromethane; chloroform;

Reference yield:

β-benzyloxycarbonylamino-cyclopentanone (635311-42-1) → 3,3-difluorocyclopentanamine (939525-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / chloroform / 3 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; In methanol; chloroform;

upstream raw materials:

[cis-(+/-)]-(3-hydroxycyclopentyl)carbamic acid phenylmethyl ester

β-benzyloxycarbonylamino-cyclopentanone

benzyl 3,3-difluorocyclopentylcarbamate

Refernces