Technology Process of DL-Valine, N-[(1,1-diMethylethoxy)carbonyl]-3-fluoro-
There total 7 articles about DL-Valine, N-[(1,1-diMethylethoxy)carbonyl]-3-fluoro- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrabutylammomium bromide; sodium hydrogencarbonate;
In
water; ethyl acetate;
at 0 ℃;
for 0.5h;
Autoclave;
DOI:10.1021/ol501051p
- Guidance literature:
-
di-tert-butyl dicarbonate; 2-amino-3-fluoro-3-methylbutanoic acid;
With
triethylamine;
In
methanol;
for 18h;
With
hydrogenchloride;
In
water;
pH=2 - 3;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2-(pyridin-2-yl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole; ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate; triethylamine tris(hydrogen fluoride); iron(II) tetrafluoroborate hexahydrate / dichloromethane / 0.17 h / 0 - 23 °C / Autoclave; Inert atmosphere; Molecular sieve
2: triethylamine; dmap / dichloromethane / 1 h / 20 °C / Autoclave
3: caesium carbonate / methanol / 20 °C / Autoclave
4: tetrabutylammomium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium hypochlorite / water; ethyl acetate / 0.5 h / 0 °C / Autoclave
With
dmap; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; iron(II) tetrafluoroborate hexahydrate; 2-(pyridin-2-yl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole; tetrabutylammomium bromide; sodium hydrogencarbonate; caesium carbonate; triethylamine tris(hydrogen fluoride); triethylamine; ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate;
In
methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/ol501051p
