ethyl 3,4-difluoro-2-((triMethylsilyl)ethynyl)phenylcarbaMate

Base Information

Chemical Name:ethyl 3,4-difluoro-2-((triMethylsilyl)ethynyl)phenylcarbaMate
CAS No.:1268052-96-5
Molecular Formula:C14H17F2NO2Si
Molecular Weight:297.377
Hs Code.:
Mol file:1268052-96-5.mol

Synonyms:ethyl 3,4-difluoro-2-((triMethylsilyl)ethynyl)phenylcarbaMate

Suppliers and Price of ethyl 3,4-difluoro-2-((triMethylsilyl)ethynyl)phenylcarbaMate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl(3,4-difluoro-2-((trimethylsilyl)ethynyl)phenyl)carbamate 95+%
1g
$ 589.00

Chemenu
ethyl(3,4-difluoro-2-((trimethylsilyl)ethynyl)phenyl)carbamate 95%
1g
$ 557.00

American Custom Chemicals Corporation
ETHYL-(3,4-DIFLUORO-2-((TRIMETHYLSILYL)ETHYNYL)PHENYL)CARBAMATE 95.00%
5MG
$ 501.93

Alichem
Ethyl(3,4-difluoro-2-((trimethylsilyl)ethynyl)phenyl)carbamate
1g
$ 489.60

Total 7 raw suppliers

Chemical Property of ethyl 3,4-difluoro-2-((triMethylsilyl)ethynyl)phenylcarbaMate

Chemical Property:

Boiling Point:291.4±40.0 °C(Predicted)
PKA:11.61±0.70(Predicted)
PSA：41.82000
Density:1.14±0.1 g/cm3(Predicted)
LogP:3.77570
Storage Temp.:2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl(3,4-difluoro-2-((trimethylsilyl)ethynyl)phenyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 3,4-difluoro-2-((triMethylsilyl)ethynyl)phenylcarbaMate

There total 3 articles about ethyl 3,4-difluoro-2-((triMethylsilyl)ethynyl)phenylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1268052-94-3
(3,4-difluoro-2-iodophenyl)carbamic acid ethyl ester

: 1066-54-2
trimethylsilylacetylene

: 1268052-96-5
(3,4-difluoro-2-trimethylsilanylethynylphenyl)carbamic acid ethyl ester

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: 2145-85-9
(3,4-difluorophenyl)carbamic acid ethyl ester

: 1268052-96-5
(3,4-difluoro-2-trimethylsilanylethynylphenyl)carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1.17 h / -78 °C

1.2: 0.58 h / -78 °C

2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 5 h / 20 °C

With copper(l) iodide; sec.-butyllithium; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; cyclohexane;

Reference yield:

: 3863-11-4
3,4-difluoroaniline

: 1268052-96-5
(3,4-difluoro-2-trimethylsilanylethynylphenyl)carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C

2.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1.17 h / -78 °C

2.2: 0.58 h / -78 °C

3.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 5 h / 20 °C

With pyridine; copper(l) iodide; sec.-butyllithium; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; cyclohexane;