Carbamic acid, N-[4-(difluoromethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, N-[4-(difluoromethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester
• CAS No.: 947179-19-3
• Molecular Formula: C₉H₁₂F₂N₂O₂S
• Molecular Weight: 250.269
• Hs Code.: 2934100090
• Mol file: 947179-19-3.mol

Synonyms:Carbamic acid, N-[4-(difluoromethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester;tert-Butyl (4-(difluoromethyl)-thiazol-2-yl)carbamate

Chemical Property of Carbamic acid, N-[4-(difluoromethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 79.46000
• LogP: 3.50070

Purity/Quality:

95% ^*data from raw suppliers

tert-Butyl (4-(difluoromethyl)-thiazol-2-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, N-[4-(difluoromethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester

There total 3 articles about Carbamic acid, N-[4-(difluoromethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(4-formyl-thiazol-2-yl)-carbamic acid tert-butyl ester (494769-34-5) → (4-Difluoromethylthiazol-2-yl)-carbamic acid tert-butyl ester (947179-19-3)

Guidance literature:

(4-formyl-thiazol-2-yl)-carbamic acid tert-butyl ester; With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

methyl 2-[[(tert-butoxy)carbonyl]amino]-1,3-thiazole-4-carboxylate (850429-62-8) → (4-Difluoromethylthiazol-2-yl)-carbamic acid tert-butyl ester (947179-19-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: diethylamino-sulfur trifluoride / ethanol; dichloromethane / 20 °C

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

(4-hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester (494769-44-7) → (4-Difluoromethylthiazol-2-yl)-carbamic acid tert-butyl ester (947179-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: diethylamino-sulfur trifluoride / ethanol; dichloromethane / 20 °C

With diethylamino-sulfur trifluoride; Dess-Martin periodane; In ethanol; dichloromethane;

upstream raw materials:

(4-formyl-thiazol-2-yl)-carbamic acid tert-butyl ester

methyl 2-[[(tert-butoxy)carbonyl]amino]-1,3-thiazole-4-carboxylate

(4-hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester

Downstream raw materials:

2-amino-4-difluoromethylthiazole

Refernces

• 1、 -. "6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION". Page/Page column 126. . Retrieved 2014/03/26.