5,7-difluorochroman-4-amine

Base Information

• Chemical Name: 5,7-difluorochroman-4-amine
• CAS No.: 886762-87-4
• Molecular Formula: C9H9F2NO
• Molecular Weight: 185.17
• Mol file: 886762-87-4.mol

Synonyms:5,7-Difluorochroman-4-amine;

Chemical Property of 5,7-difluorochroman-4-amine

Chemical Property:

• Vapor Pressure: 0.269mmHg at 25°C
• Boiling Point: 204.062°C at 760 mmHg
• Flash Point: 77.214°C
• PSA: 35.25000
• Density: 1.292g/cm³
• LogP: 2.44740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,7-Difluorochroman-4-amine is used as a reagent in the preparation of 2-amino-4-naphthylamino-6H-1,3,5-triazines as herbicides and plant growth regulators.

Technology Process of 5,7-difluorochroman-4-amine

There total 3 articles about 5,7-difluorochroman-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-azido-5,7-difluorochromane (1027098-55-0) → 5,7-difluorochroman-4-amine (886762-87-4,1212993-64-0)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 20 ℃; for 5h; under 2280.15 Torr;

Reference yield:

5,7-difluorochroman-4-one (844648-22-2) → 5,7-difluorochroman-4-amine (886762-87-4,1212993-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 2 h / 20 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 0 - 20 °C / 760.05 Torr

With sodium tetrahydroborate; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol;

Reference yield:

5,7-difluoro-3,4-dihydro-2H-chromen-4-ol (917248-51-2) → 5,7-difluorochroman-4-amine (886762-87-4,1212993-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 2 h / 20 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 0 - 20 °C / 760.05 Torr

With diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol;

upstream raw materials:

4-azido-5,7-difluorochromane

5,7-difluorochroman-4-one

5,7-difluoro-3,4-dihydro-2H-chromen-4-ol

Refernces

• 1、 -. "IMIDAZO [1, 2-A] PYRAZINE DERIVATIVES AND THEIR USE AS ACID PUMP ANTAGONISTS". Page/Page column 43-44. . Retrieved 2008/12/05.