2-Morpholinemethanamine, 4-[(4-fluorophenyl)methyl]-, (2R)-

Base Information

Chemical Name:2-Morpholinemethanamine, 4-[(4-fluorophenyl)methyl]-, (2R)-
CAS No.:156334-90-6
Molecular Formula:C12H17FN2O
Molecular Weight:224.27
Hs Code.:
Mol file:156334-90-6.mol

Synonyms:2-Morpholinemethanamine, 4-[(4-fluorophenyl)methyl]-, (R)-;

Suppliers and Price of 2-Morpholinemethanamine, 4-[(4-fluorophenyl)methyl]-, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-Morpholinemethanamine, 4-[(4-fluorophenyl)methyl]-, (2R)-

Chemical Property:

PSA：38.49000
LogP:1.62340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Morpholinemethanamine, 4-[(4-fluorophenyl)methyl]-, (2R)-

There total 12 articles about 2-Morpholinemethanamine, 4-[(4-fluorophenyl)methyl]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 156334-88-2
(S)-(+)-N-<<4-(4-fluorobenzyl)-2-morpholinyl>methyl>phthalimide

: 156334-90-6
(R)-(+)-<4-(4-fluorobenzyl)-2-morpholinyl>methylamine

Guidance literature:: With hydrazine hydrate; In ethanol; for 0.5h; Heating;

Reference yield:

: 156816-57-8
(S)-2-Azidomethyl-4-(4-fluoro-benzyl)-morpholine

: 156334-90-6
(R)-(+)-<4-(4-fluorobenzyl)-2-morpholinyl>methylamine

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at -5 - 20 ℃; for 1.5h; Yield given;
DOI:10.1248/cpb.42.877

Reference yield:

: 22116-33-2
2-(4-fluoro-benzyl-amino)-ethanol

: 156334-90-6
(R)-(+)-<4-(4-fluorobenzyl)-2-morpholinyl>methylamine

Guidance literature:: Multi-step reaction with 7 steps

1: 4 h / Ambient temperature

2: conc. H₂SO₄ / 0.5 h / 150 °C

3: 96 percent / H₂O, formamide / 6 h / Heating

4: 64 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h / 5 - 20 °C

6: sodium azide / dimethylformamide / 2 h / 120 °C

7: 70percent sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 1.5 h / -5 - 20 °C

With dmap; sodium azide; sulfuric acid; water; formamide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.42.877