1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone

Base Information

Chemical Name:1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone
CAS No.:1110663-22-3
Molecular Formula:C8H6ClFO2
Molecular Weight:188.586
Hs Code.:2914500090
DSSTox Substance ID:DTXSID90697483
Wikidata:Q82627397
Mol file:1110663-22-3.mol

Synonyms:1-(4-CHLORO-2-FLUORO-6-HYDROXYPHENYL)ETHANONE;1110663-22-3;1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethan-1-one;SCHEMBL3019010;DTXSID90697483;MFCD13152285;AKOS016003888;AS-66540;CS-0155138;FT-0744098;C71371

Suppliers and Price of 1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone 95+%
1g
$ 535.00

Apolloscientific
1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone 95+%
250mg
$ 212.00

American Custom Chemicals Corporation
1-(4-CHLORO-2-FLUORO-6-HYDROXYPHENYL)ETHANONE 95.00%
5G
$ 3349.50

Ambeed
1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone 95+%
100mg
$ 72.00

Alichem
1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone
1g
$ 529.20

AK Scientific
1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone
100mg
$ 232.00

Total 16 raw suppliers

Chemical Property of 1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone

Chemical Property:

PSA：37.30000
LogP:2.38730
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:188.0040353
Heavy Atom Count:12
Complexity:186

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=C(C=C(C=C1F)Cl)O

Technology Process of 1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone

There total 1 articles about 1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1110663-19-8
1-(2-benzyloxy-4-chloro-6-fluorophenyl)ethanone

: 1110663-22-3
1-(4-chloro-6-fluoro-2-hydroxyphenyl)ethanone

Guidance literature:: With hydrogen; 1% Pd/C; In methanol; at 20 ℃;

Reference yield:

: 1110663-22-3
1-(4-chloro-6-fluoro-2-hydroxyphenyl)ethanone

: 589-21-9
(4-bromophenyl)hydrazine

: 1370468-13-5
C₁₄H₈BrClFNO

Guidance literature:: 1-(4-chloro-6-fluoro-2-hydroxyphenyl)ethanone; (4-bromophenyl)hydrazine; With acetic acid; In ethanol; Reflux;

at 110 ℃;
DOI:10.1016/j.bmcl.2016.08.097

Reference yield:

: 1110663-22-3
1-(4-chloro-6-fluoro-2-hydroxyphenyl)ethanone

: C₃₅H₃₃ClFN₅O₄

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / ethanol / Reflux

1.2: polyphosphoric acid / 110 °C

2.1: toluene-4-sulfonic acid / o-xylene / 15 h / 170 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / tetrahydrofuran / 90 °C

4.1: hydrogenchloride / methanol; water

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; ethanol; o-xylene; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.08.097