1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride

Base Information

• Chemical Name: 1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride
• CAS No.: 847556-27-8
• Molecular Formula: C₁₈H₁₈N₂O₂
• Molecular Weight: 294.353
• Hs Code.: 2934999090
• Mol file: 847556-27-8.mol

Synonyms:1,1-Diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride;hexahydro-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazin-3-one;1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-one;

Chemical Property of 1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride

Chemical Property:

• PSA: 41.57000
• LogP: 3.42290

Purity/Quality:

98%min ^*data from raw suppliers

1,1-Diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-onehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride

There total 7 articles about 1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1,1-dimethyl-ethyl)-tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxylate → 1,1-diphenyltetrahydro-1H-oxazolo[3,4-α]pyrazin-3(5H)-one (847555-93-5,847556-27-8,847556-28-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2008.05.098

Reference yield: 92.0%

7-benzyl-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]-piperazin-3-one (847555-98-0) → 1,1-diphenyltetrahydro-1H-oxazolo[3,4-α]pyrazin-3(5H)-one (847555-93-5,847556-27-8,847556-28-9)

Guidance literature:

7-benzyl-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]-piperazin-3-one; With carbonochloridic acid 1-chloro-ethyl ester; In 1,2-dichloro-ethane; at 60 ℃; for 5h;

With methanol; for 2.5h; Product distribution / selectivity; Heating / reflux;

Reference yield: 87.0%

3-oxo-1,1-diphenyltetrahydrooxazolo[3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester (847553-76-8) → 1,1-diphenyltetrahydro-1H-oxazolo[3,4-α]pyrazin-3(5H)-one (847555-93-5,847556-27-8,847556-28-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1021/acs.jmedchem.0c02223

upstream raw materials:

7-benzyl-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]-piperazin-3-one

(1,4-dibenzyl-piperazin-2-yl)-diphenyl-methanol

di-tert-butyl dicarbonate

diphenyl(piperazin-2-yl)methanol