TERT-BUTYL 2,3-DIHYDRO-1H-SPIRO[ISOQUINOLINE-4,4'-PIPERIDINE]-1'-CARBOXYLATE

Base Information

Chemical Name:TERT-BUTYL 2,3-DIHYDRO-1H-SPIRO[ISOQUINOLINE-4,4'-PIPERIDINE]-1'-CARBOXYLATE
CAS No.:159634-80-7
Molecular Formula:C18H26N2O2
Molecular Weight:302.41
Hs Code.:2933990090
Mol file:159634-80-7.mol

Synonyms:TERT-BUTYL 2,3-DIHYDRO-1H-SPIRO[ISOQUINOLINE-4,4-PIPERIDINE]-1-CARBOXYLATE;2,3-Dihydro-spiro[isoquinolin-4(1H),4-piperidine]-1-carboxylic acid tert-butyl ester;Spiro[isoquinoline-4(1H),4-piperidine]-1-carboxylic acid, 2,3-dihydro-, 1,1-diMethylethyl ester;1,2,3,4-tetrahydrospiro[isoquinolin-4,4-piperidine]-1-carboxylic acid, 1,1-diMethylethyl ester

Suppliers and Price of TERT-BUTYL 2,3-DIHYDRO-1H-SPIRO[ISOQUINOLINE-4,4'-PIPERIDINE]-1'-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Synthonix
tert-Butyl2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylate 95+%
25g
$ 3930.00

Matrix Scientific
tert-Butyl2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylate 95+%
1g
$ 1898.00

Crysdot
tert-Butyl2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylate 95+%
1g
$ 614.00

Chemenu
tert-Butyl2,3-dihydro-1H-spiro[isoquinoline-4,4''-piperidine]-1''-carboxylate 95%
1g
$ 580.00

Alichem
tert-Butyl2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylate
1g
$ 510.00

AK Scientific
tert-Butyl2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylate
1g
$ 2612.00

Total 28 raw suppliers

Chemical Property of TERT-BUTYL 2,3-DIHYDRO-1H-SPIRO[ISOQUINOLINE-4,4'-PIPERIDINE]-1'-CARBOXYLATE

Chemical Property:

Boiling Point:428.5±45.0 °C(Predicted)
PKA:9.44±0.20(Predicted)
Flash Point:212.949oC
PSA：41.57000
Density:1.13±0.1 g/cm3(Predicted)
LogP:3.32520

Purity/Quality:

≥99% ^*data from raw suppliers

tert-Butyl2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 2,3-DIHYDRO-1H-SPIRO[ISOQUINOLINE-4,4'-PIPERIDINE]-1'-CARBOXYLATE

There total 8 articles about TERT-BUTYL 2,3-DIHYDRO-1H-SPIRO[ISOQUINOLINE-4,4'-PIPERIDINE]-1'-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1,3-dihydro-1,3-dihydroxyspiro[4H-2-benzofuran-4,4'-piperidine]-1'-carboxylic acid, 1,1-dimethylethyl ester

: 159634-80-7
1,2,3,4-tetrahydrospiro[isoquinolin-4,4'-piperidine]-1'-carboxylic acid, 1,1-dimethylethyl ester

Guidance literature:: With sodium cyanoborohydride; In methanol;

Reference yield:

: 906369-83-3
C₂₄H₂₉N₃O₆S

: 159634-80-7
1,2,3,4-tetrahydrospiro[isoquinolin-4,4'-piperidine]-1'-carboxylic acid, 1,1-dimethylethyl ester

Guidance literature:: With lithium hydroxide; mercaptoacetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.05.082

Reference yield:

: C₁₉H₂₁N₃O₄S

: 159634-80-7
1,2,3,4-tetrahydrospiro[isoquinolin-4,4'-piperidine]-1'-carboxylic acid, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / ethyl acetate

2: HSCH₂COOH; LiOH / dimethylformamide

With lithium hydroxide; sodium hydroxide; mercaptoacetic acid; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.05.082