1'-(TERT-BUTOXYCARBONYL)-2-OXOSPIRO[INDOLINE-3,4'-PIPERIDINE]-5-CARBOXYLIC ACID

Base Information

Chemical Name:1'-(TERT-BUTOXYCARBONYL)-2-OXOSPIRO[INDOLINE-3,4'-PIPERIDINE]-5-CARBOXYLIC ACID
CAS No.:946135-52-0
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:2933399090
Mol file:946135-52-0.mol

Synonyms:-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylic acid;1'-(TERT-BUTOXYCARBONYL)-2-OXOSPIRO[INDOLINE-3,4'-PIPERIDINE]-5-CARBOXYLIC ACID;Spiro[3H-indole-3,4′-piperidine]-1′,5-dicarboxylic acid, 1,2-dihydro-2-oxo-, 1′-…;1'-[(2-methylpropan-2-yl)oxycarbonyl]-2-oxospiro[1H-indole-3,4'-piperidine]-5-carboxylic acid

Suppliers and Price of 1'-(TERT-BUTOXYCARBONYL)-2-OXOSPIRO[INDOLINE-3,4'-PIPERIDINE]-5-CARBOXYLIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Synthonix
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylicacid 95+%
5g
$ 3380.00

Matrix Scientific
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylicacid 95+%
1g
$ 1898.00

Chemenu
1''-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4''-piperidine]-5-carboxylicacid 95%
1g
$ 580.00

American Custom Chemicals Corporation
1'-(TERT-BUTOXYCARBONYL)-2-OXOSPIRO(INDOLINE-3,4'-PIPERIDINE)-5-CARBOXYLIC ACID 95.00%
5G
$ 3811.50

Alichem
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylicacid
1g
$ 535.00

AK Scientific
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylicacid
1g
$ 2612.00

Total 19 raw suppliers

Chemical Property of 1'-(TERT-BUTOXYCARBONYL)-2-OXOSPIRO[INDOLINE-3,4'-PIPERIDINE]-5-CARBOXYLIC ACID

Chemical Property:

Boiling Point:567.093oC at 760 mmHg
Flash Point:296.768oC
PSA：99.43000
Density:1.345g/cm3
LogP:2.62860
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1'-(TERT-BUTOXYCARBONYL)-2-OXOSPIRO[INDOLINE-3,4'-PIPERIDINE]-5-CARBOXYLIC ACID

There total 9 articles about 1'-(TERT-BUTOXYCARBONYL)-2-OXOSPIRO[INDOLINE-3,4'-PIPERIDINE]-5-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 946135-54-2
1'-tert-butyl 5-ethyl-2-oxospiro[indoline-3,4'-piperidine]-1',5-dicarboxylate

: 946135-52-0
1'-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 55 ℃; for 8h;
DOI:10.3390/11090700

Reference yield:

: 118753-70-1
N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine

: 102359-00-2
2-oxoindoline-5-carboxylic acid

: 946135-52-0
1'-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylic acid

Guidance literature:: 2-oxoindoline-5-carboxylic acid; With lithium hexamethyldisilazane; In 1,2-dimethoxyethane; at -78 - -30 ℃;

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine; In 1,2-dimethoxyethane; at -30 - 20 ℃;
DOI:10.1021/jm201542d

Reference yield:

: 946135-56-4
C₂₁H₂₀N₂O₇Cl₆

: 946135-52-0
1'-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: zinc; acetic acid / 2 h

2: 92 percent / dioxane / 1 h

3: 91 percent / aq. sodium hydroxide / methanol / 8 h / 55 °C

With sodium hydroxide; acetic acid; zinc; In 1,4-dioxane; methanol;
DOI:10.3390/11090700