(RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol

Base Information

Chemical Name:(RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol
CAS No.:949095-98-1
Molecular Formula:C18H19NOS
Molecular Weight:297.421
Hs Code.:2934999090
Mol file:949095-98-1.mol

Synonyms:4-[3-(methylamino)-1-thiophen-2-ylpropyl]naphthalen-1-ol;

Suppliers and Price of (RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Para-NaphtholDuloxetine
250mg
$ 1285.00

Crysdot
DuloxetinemetabolitePara-NaphtholDuloxetine 98+%
25mg
$ 400.00

Chemenu
4-(3-(Methylamino)-1-(thiophen-2-yl)propyl)naphthalen-1-ol 98%
100mg
$ 458.00

Alichem
DuloxetinemetabolitePara-NaphtholDuloxetine
100mg
$ 490.00

Alichem
DuloxetinemetabolitePara-NaphtholDuloxetine
50mg
$ 349.65

Total 26 raw suppliers

Chemical Property of (RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol

Chemical Property:

PSA：60.50000
Density:1.189
LogP:4.73920
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Sparingly), Methanol (Slightly, Sonicated)

Purity/Quality:

99%, ^*data from raw suppliers

Para-NaphtholDuloxetine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Para-Naphthol Duloxetine is an impurity of Duloxetine (D721000), an antidepressant and a dual serotonin and norepinephrine reuptake inhibitor (SNRI) (1,2). Exhibits linear pharmacokinetics in mice and is not associated in any drastic changes of blood pressure or heart rate (3).

Technology Process of (RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol

There total 2 articles about (RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136434-34-9
duloxetine hydrochloride

: 949095-98-1
(+/-)-N-methyl-3-(2-thienyl)-3-(4-hydroxy-1-naphthyl)-propylamine

: 116539-58-3,116539-59-4,116539-60-7,116817-13-1
Duloxetine

Guidance literature:: With sodium hydroxide; In toluene;

Reference yield:

: 116817-86-8
(+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate

: 949095-98-1
(+/-)-N-methyl-3-(2-thienyl)-3-(4-hydroxy-1-naphthyl)-propylamine

: 136434-34-9
duloxetine hydrochloride

Guidance literature:: (+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate; With sodium hydroxide; In water; toluene; at 25 ℃; for 0.166667h; pH=11 - 12;

With hydrogenchloride; In water; ethyl acetate; at 5 - 20 ℃; for 4.5h;