(RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol

Base Information

• Chemical Name: (RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol
• CAS No.: 949095-98-1
• Molecular Formula: C18H19NOS
• Molecular Weight: 297.421
• Hs Code.: 2934999090
• Mol file: 949095-98-1.mol

Synonyms:4-[3-(methylamino)-1-thiophen-2-ylpropyl]naphthalen-1-ol;

Chemical Property of (RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol

Chemical Property:

• PSA: 60.50000
• Density: 1.189
• LogP: 4.73920
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Sparingly), Methanol (Slightly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

Para-NaphtholDuloxetine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Para-Naphthol Duloxetine is an impurity of Duloxetine (D721000), an antidepressant and a dual serotonin and norepinephrine reuptake inhibitor (SNRI) (1,2). Exhibits linear pharmacokinetics in mice and is not associated in any drastic changes of blood pressure or heart rate (3).

Technology Process of (RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol

There total 2 articles about (RS)-4-(3-MethylaMino-1-thiophen-2-yl-propyl)-naphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

duloxetine hydrochloride (136434-34-9) → (+/-)-N-methyl-3-(2-thienyl)-3-(4-hydroxy-1-naphthyl)-propylamine (949095-98-1) + Duloxetine (116539-58-3,116539-59-4,116539-60-7,116817-13-1)

Guidance literature:

With sodium hydroxide; In toluene;

Reference yield:

(+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate (116817-86-8) → (+/-)-N-methyl-3-(2-thienyl)-3-(4-hydroxy-1-naphthyl)-propylamine (949095-98-1) + duloxetine hydrochloride (136434-34-9)

Guidance literature:

(+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate; With sodium hydroxide; In water; toluene; at 25 ℃; for 0.166667h; pH=11 - 12;

With hydrogenchloride; In water; ethyl acetate; at 5 - 20 ℃; for 4.5h;

upstream raw materials:

duloxetine hydrochloride

(+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate