8-METHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE

Base Information

• Chemical Name: 8-METHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE
• CAS No.: 850896-45-6
• Molecular Formula: C9H11NO
• Molecular Weight: 185.65068
• Hs Code.: 2934999090
• Mol file: 850896-45-6.mol

Synonyms:1,4-Benzoxazine, 2,3-dihydro-8-methyl- (4CI);

Chemical Property of 8-METHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 165-168 °C(Press: 15 Torr)
• PKA: 4.67±0.20(Predicted)
• PSA: 21.26000
• Density: 1.068±0.06 g/cm3(Predicted)
• LogP: 2.73930

Purity/Quality:

98% ^*data from raw suppliers

8-METHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINEHYDROCHLORIDE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-METHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE

There total 8 articles about 8-METHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-methyl-4H-benz[1,4]oxazin-3-one (102065-94-1) → 8-methyl-3,4-dihydro-2H-benz[1,4]oxazine (850896-45-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

2-chloro-N-(2-hydroxy-3-methylphenyl)-acetamide (888731-60-0) → 8-methyl-3,4-dihydro-2H-benz[1,4]oxazine (850896-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / sodium iodide / N,N-dimethyl-formamide / 0 - 80 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 7 h / 0 °C / Heating / reflux

2.2: 0 - 40 °C

With lithium aluminium tetrahydride; potassium carbonate; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

2-amino-6-methylphenol hydrobromide (888731-59-7) → 8-methyl-3,4-dihydro-2H-benz[1,4]oxazine (850896-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0 - 40 °C

2.1: potassium carbonate / sodium iodide / N,N-dimethyl-formamide / 0 - 80 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 7 h / 0 °C / Heating / reflux

3.2: 0 - 40 °C

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

8-methyl-4H-benz[1,4]oxazin-3-one

2-chloro-N-(2-hydroxy-3-methylphenyl)-acetamide

2-amino-6-methylphenol hydrobromide

4-Bromo-2-methylphenol