4(1H)-Pyridinone, 2,3-dihydro-1-[2,3,6-trifluoro-4-[(5S)-5-[(3-isoxazolylamino)methyl]-2-oxo-3-oxazolidinyl]phenyl]-

Base Information

Chemical Name:4(1H)-Pyridinone, 2,3-dihydro-1-[2,3,6-trifluoro-4-[(5S)-5-[(3-isoxazolylamino)methyl]-2-oxo-3-oxazolidinyl]phenyl]-
CAS No.:1112968-42-9
Molecular Formula:C18H15F3N4O4
Molecular Weight:408.337
Hs Code.:
Mol file:1112968-42-9.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4(1H)-Pyridinone, 2,3-dihydro-1-[2,3,6-trifluoro-4-[(5S)-5-[(3-isoxazolylamino)methyl]-2-oxo-3-oxazolidinyl]phenyl]-

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 4(1H)-Pyridinone, 2,3-dihydro-1-[2,3,6-trifluoro-4-[(5S)-5-[(3-isoxazolylamino)methyl]-2-oxo-3-oxazolidinyl]phenyl]-

There total 9 articles about 4(1H)-Pyridinone, 2,3-dihydro-1-[2,3,6-trifluoro-4-[(5S)-5-[(3-isoxazolylamino)methyl]-2-oxo-3-oxazolidinyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1112969-00-2
C₂₃H₂₃F₃N₄O₆

: 1112968-42-9
{(5S)-5-[(isoxazole-3-amino)methyl]-3-[(2,3,5-trifluoro-4-(4-oxo-2,3-dihydropyridine-1)phenyl)]-2-oxazolidione}

Guidance literature:: C₂₃H₂₃F₃N₄O₆; With hydrogenchloride; In ethanol; water; ethyl acetate; at 0 - 20 ℃;

With sodium carbonate; sodium hydroxide; In ethanol; water; ethyl acetate; pH=~ 4 - ~ 8.0; Product distribution / selectivity;

Reference yield:

: 5580-79-0
2,3,4,5-tetrafluoro-1-nitrobenzene

: 1112968-42-9
{(5S)-5-[(isoxazole-3-amino)methyl]-3-[(2,3,5-trifluoro-4-(4-oxo-2,3-dihydropyridine-1)phenyl)]-2-oxazolidione}

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / 1-methylpiperidin-2-one / -10 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2.67 h / 0 - 20 °C

3.1: ammonium cerium(IV) nitrate / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

4.1: water; iron; ammonium chloride / ethanol / 0.83 h / 100 - 105 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

5.2: 0 - 20 °C

5.3: 2 h / 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

6.2: -78 - 20 °C

7.1: triethylamine / dichloromethane / 0 - 20 °C

8.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

8.2: 2 h / 35 °C

9.1: hydrogenchloride / tetrahydrofuran / 2 h / 0 - 20 °C

9.2: 0.25 h / pH ~ 8

With hydrogenchloride; ammonium cerium(IV) nitrate; potassium tert-butylate; water; iron; sodium hydride; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1-methylpiperidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1112968-95-2
C₁₁H₉F₃N₂O

: 1112968-42-9
{(5S)-5-[(isoxazole-3-amino)methyl]-3-[(2,3,5-trifluoro-4-(4-oxo-2,3-dihydropyridine-1)phenyl)]-2-oxazolidione}

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0 - 20 °C

1.3: 2 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 2 h / 35 °C

5.1: hydrogenchloride / tetrahydrofuran / 2 h / 0 - 20 °C

5.2: 0.25 h / pH ~ 8

With hydrogenchloride; potassium tert-butylate; sodium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;