3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane

Base Information

Chemical Name:3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane
CAS No.:959493-37-9
Molecular Formula:C₁₄H₂₁N₃
Molecular Weight:231.341
Hs Code.:2933990090
DSSTox Substance ID:DTXSID10390505
Wikidata:Q82187314
ChEMBL ID:CHEMBL1370553
Mol file:959493-37-9.mol

Synonyms:3-(pyridin-2-yl)-3,9-diazaspiro[5.5]undecane;959493-37-9;3-pyridin-2-yl-3,9-diazaspiro[5.5]undecane;NCGC00011874;CHEMBL1370553;SCHEMBL13050537;DTXSID10390505;PCOP-639951;A900996;J-510946;(1R,2R)-methyl 1-((2S,4S)-4-(((4-bromophenyl)sulfonyl)oxy)pyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride

Suppliers and Price of 3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane 95+%
1g
$ 772.00

Chemenu
3-(pyridin-2-yl)-3,9-diazaspiro[5.5]undecane 95%
1g
$ 729.00

American Custom Chemicals Corporation
3-(PYRIDIN-2-YL)-3,9-DIAZASPIRO-[5.5]-UNDECANE 95.00%
5MG
$ 503.56

Alichem
3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane
25g
$ 5382.78

Alichem
3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane
10g
$ 2729.58

Alichem
3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane
5g
$ 2229.76

Total 9 raw suppliers

Chemical Property of 3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane

Chemical Property:

PSA：28.16000
LogP:2.44540
Storage Temp.:2-8°C
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:231.173547683
Heavy Atom Count:17
Complexity:238

Purity/Quality:

97% ^*data from raw suppliers

3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC12CCN(CC2)C3=CC=CC=N3

Technology Process of 3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane

There total 3 articles about 3-(Pyridin-2-yl)-3,9-diazaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 9-(pyridin-2-yl)-3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester

: 959493-37-9
C₁₄H₂₁N₃

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/acs.jmedchem.7b01248

Reference yield:

: 173405-78-2
tert-butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate

: 959493-37-9
C₁₄H₂₁N₃

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine; sodium tertiary butoxide / 1,4-dioxane / 0.33 h / 100 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifluoroacetic acid; sodium tertiary butoxide; dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/acs.jmedchem.7b01248

Reference yield:

: 109-04-6
2-bromo-pyridine

: 959493-37-9
C₁₄H₂₁N₃

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium-t-butoxide; triethylamine / toluene / 8 h / 110 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium-t-butoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; In dichloromethane; toluene;