2,8-DIAZASPIRO[4.5]DECAN-3-ONE HYDROCHLORIDE

Base Information

• Chemical Name: 2,8-DIAZASPIRO[4.5]DECAN-3-ONE HYDROCHLORIDE
• CAS No.: 945892-88-6
• Molecular Formula: C8H14N2O.Cl H
• Molecular Weight: 190.673
• Hs Code.: 2933990090
• Mol file: 945892-88-6.mol

Synonyms:2,8-DIAZASPIRO[4.5]DECAN-3-ONE HYDROCHLORIDE;2,8-Diazaspiro[4.5]decan-3-one,(Hydrochloride) (1:1)

Chemical Property of 2,8-DIAZASPIRO[4.5]DECAN-3-ONE HYDROCHLORIDE

Chemical Property:

• PSA: 44.62000
• LogP: 1.28280
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2,8-Diazaspiro[4.5]decan-3-onehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,8-DIAZASPIRO[4.5]DECAN-3-ONE HYDROCHLORIDE

There total 1 articles about 2,8-DIAZASPIRO[4.5]DECAN-3-ONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-oxo-2,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester (169206-67-1) → 2,8-diazaspiro[4.5]decan-3-one hydrochloride (945892-88-6,1417301-86-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield: 26.0%

8-chloro-1-cyclopropyl-N-(2,4-dichlorobenzyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide (874483-03-1) + 2,8-diazaspiro[4.5]decan-3-one hydrochloride (945892-88-6,1417301-86-0) → 8-Chloro-1-cyclopropyl-N-(2,4-dichlorobenzyl)-6-fluoro-4-oxo-7-(3-oxo-2,8-diazaspiro[4.5]dec-8-yl)-1,4-dihydroquinoline-3-carboxamide (945892-79-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 120 ℃; for 48h;

Reference yield:

2,8-diazaspiro[4.5]decan-3-one hydrochloride (945892-88-6,1417301-86-0) + tert-butyl-4-bromobenzoate (59247-47-1) → tert-butyl 4-(3-oxo-2,8-diazaspiro[4.5]decan-2-yl)benzoate

Guidance literature:

With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; at 110 ℃; for 16h; Inert atmosphere;

upstream raw materials:

3-oxo-2,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester

Downstream raw materials:

8-Chloro-1-cyclopropyl-N-(2,4-dichlorobenzyl)-6-fluoro-4-oxo-7-(3-oxo-2,8-diazaspiro[4.5]dec-8-yl)-1,4-dihydroquinoline-3-carboxamide

2,8-diazaspiro[4.5]decane-3-one

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