methyl 3-(tert-butoxycarbonylamino)-4-hydroxybutanoate

Base Information

• Chemical Name: methyl 3-(tert-butoxycarbonylamino)-4-hydroxybutanoate
• CAS No.: 942297-60-1
• Molecular Formula: C₁₀H₁₉NO₅
• Molecular Weight: 233.265
• Hs Code.: 2924199090
• Mol file: 942297-60-1.mol

Synonyms:methyl 3-(tert-butoxycarbonylamino)-4-hydroxybutanoate;DL-3-tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester;

Chemical Property of methyl 3-(tert-butoxycarbonylamino)-4-hydroxybutanoate

Chemical Property:

• PSA: 88.35000
• LogP: 0.63950
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl3-((tert-butoxycarbonyl)amino)-4-hydroxybutanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(tert-butoxycarbonylamino)-4-hydroxybutanoate

There total 3 articles about methyl 3-(tert-butoxycarbonylamino)-4-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2-(tert-butoxycarbonylamino)-4-methoxy-4-oxobutanoic acid (856417-64-6) → DL-3-tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester (942297-60-1)

Guidance literature:

2-(tert-butoxycarbonylamino)-4-methoxy-4-oxobutanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at -10 ℃; for 0.166667h;

In tetrahydrofuran; methanol; at 0 - 20 ℃; for 3.33h;

Reference yield:

C14H20N2O8 → DL-3-tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester (942297-60-1)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 ℃; for 5h;

DOI:10.1016/j.ejmech.2016.04.069

Reference yield:

aspartic acid methyl ester hydrochloride (129902-07-4) → DL-3-tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester (942297-60-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; 1,4-dioxane / 20 °C

2: dichloromethane / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; ethanol / 5 h / 0 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2016.04.069

upstream raw materials:

2-(tert-butoxycarbonylamino)-4-methoxy-4-oxobutanoic acid

aspartic acid methyl ester hydrochloride

Refernces

• 1、 -. "Heteroarylpyrrolopyridinones active as kinase inhibitors". Page/Page column 18. . Retrieved 2008/06/13.