(Z)-6-bromonicotinaldehyde oxime

Base Information

• Chemical Name: (Z)-6-bromonicotinaldehyde oxime
• CAS No.: 864266-28-4
• Molecular Formula: C6H5BrN2O
• Molecular Weight: 201.023
• Mol file: 864266-28-4.mol

Synonyms:(Z)-6-bromonicotinaldehyde oxime;

Chemical Property of (Z)-6-bromonicotinaldehyde oxime

Chemical Property:

• PSA: 45.48000
• LogP: 1.65220
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(Z)-6-Bromonicotinaldehydeoxime 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-6-bromonicotinaldehyde oxime

There total 2 articles about (Z)-6-bromonicotinaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromonicotinaldehyde (149806-06-4) → C6H5BrN2O (864266-28-4)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol;

DOI:10.1002/cjoc.201300366

Reference yield:

2-bromo-5-(hydroxymethyl)pyridine (122306-01-8) → C6H5BrN2O (864266-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; fluorosulfonyl fluoride; dimethyl sulfoxide / 20 °C

2: hydroxylamine hydrochloride; potassium carbonate / 20 °C

With fluorosulfonyl fluoride; hydroxylamine hydrochloride; potassium carbonate; dimethyl sulfoxide;

DOI:10.1002/ejoc.201900478

Reference yield:

C6H5BrN2O (864266-28-4) → 2-bromo-5-cyanopyridine (139585-70-9)

Guidance literature:

With fluorosulfonyl fluoride; potassium carbonate; at 20 ℃; for 12h;

DOI:10.1002/ejoc.201900478

upstream raw materials:

6-bromonicotinaldehyde

2-bromo-5-(hydroxymethyl)pyridine

Downstream raw materials:

2-bromo-5-cyanopyridine

Refernces

• 1、 Jiang, Ying,Sun, Bing,Fang, Wan-Yin,Qin, Hua-Li. "A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH2OH) to Nitriles (RCN) Mediated by SO2F2". supporting information. p. 3190 - 3194. Retrieved 2019/05/21.
• 2、 Yang, Yindi,Zhang, Min,Zhu, Yiwen,Zhang, Li,Xie, Qiqiang,Song, Liping,Deng, Hongmei. "Regioselective synthesis of 2,6-dimethyl-3,5-bis[(3-aryl-5-trifluoromethyl) -isoxazol-4-carbonyl]-pyridine derivatives". . p. 950 - 954. Retrieved 2013/08/23.