DI-TERT-BUTYL [5-BROMO-3-METHYLPYRIDIN-2-YL]IMIDODICARBONATE

Base Information

Chemical Name:DI-TERT-BUTYL [5-BROMO-3-METHYLPYRIDIN-2-YL]IMIDODICARBONATE
CAS No.:497159-91-8
Molecular Formula:C16H23BrN2O4
Molecular Weight:387.27
Hs Code.:
Mol file:497159-91-8.mol

Synonyms:DI-TERT-BUTYL [5-BROMO-3-METHYLPYRIDIN-2-YL]IMIDODICARBONATE;2-(N,N-BisBOC-amino)-5-bromo-3-methylpyridine

Suppliers and Price of DI-TERT-BUTYL [5-BROMO-3-METHYLPYRIDIN-2-YL]IMIDODICARBONATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(N,N-BisBOC-amino)-5-bromo-3-methylpyridine
1g
$ 330.00

TRC
2-(N,N-BisBOC-amino)-5-bromo-3-methylpyridine
500mg
$ 230.00

SynChem
2-(N,N-BisBOC-amino)-5-bromo-3-methylpyridine 95%
1 g
$ 150.00

SynChem
2-(N,N-BisBOC-amino)-5-bromo-3-methylpyridine 95%
5 g
$ 600.00

Crysdot
Di-tert-butyl[5-bromo-3-methylpyridin-2-yl]imidodicarbonate 95+%
5g
$ 470.00

Chemenu
Di-tert-butyl[5-bromo-3-methylpyridin-2-yl]imidodicarbonate 95%
5g
$ 444.00

American Custom Chemicals Corporation
DI-TERT-BUTYL-[5-BROMO-3-METHYLPYRIDIN-2-YL]IMIDODICARBONATE 95.00%
5MG
$ 504.41

Alichem
Di-tert-butyl[5-bromo-3-methylpyridin-2-yl]imidodicarbonate
5g
$ 395.52

AK Scientific
2-(N,N-BisBOC-amino)-5-bromo-3-methylpyridine
1g
$ 251.00

Total 15 raw suppliers

Chemical Property of DI-TERT-BUTYL [5-BROMO-3-METHYLPYRIDIN-2-YL]IMIDODICARBONATE

Chemical Property:

PSA：68.73000
LogP:4.82910
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(N,N-BisBOC-amino)-5-bromo-3-methylpyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of DI-TERT-BUTYL [5-BROMO-3-METHYLPYRIDIN-2-YL]IMIDODICARBONATE

There total 1 articles about DI-TERT-BUTYL [5-BROMO-3-METHYLPYRIDIN-2-YL]IMIDODICARBONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 497159-91-8
2-[N,N-bis(tert-butoxycarbonyl)amino]-5-bromo-3-methylpyridine

Guidance literature:: With dmap; In tert-butyl alcohol;
DOI:10.1016/j.bmc.2003.12.039

Reference yield:

: 497159-91-8
2-[N,N-bis(tert-butoxycarbonyl)amino]-5-bromo-3-methylpyridine

: 685133-74-8
2-benzyloxymethyl-3-(6-tert-butoxycarbonylamino-5-methylpyridin-3-yl)-2-hydroxymethylpropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 59 percent / (PPh₃)2PdCl₂ / 1,2-dichloro-ethane / 48 h / 90 °C

2.1: 59 percent / Bu₄NF / tetrahydrofuran / 20 °C

3.1: 77 percent / PPh₃; CBr₄ / CH₂Cl₂ / 3 h / 0 - 20 °C

4.1: 59 percent / NaH / tetrahydrofuran / -70 - 20 °C

5.1: 60 percent / LDA / tetrahydrofuran; heptane; ethylbenzene / 0 - 20 °C

6.1: 60 percent / KOH / CH₂Cl₂; ethanol; H₂O / 96 h / 20 °C

7.1: BOP; DIPEA / tetrahydrofuran / 5 h / 20 °C

7.2: 72 percent / LiBH₄ / ethanol / 0.67 h

With potassium hydroxide; carbon tetrabromide; tetrabutyl ammonium fluoride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; ethylbenzene; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2003.12.039

Reference yield:

: 497159-91-8
2-[N,N-bis(tert-butoxycarbonyl)amino]-5-bromo-3-methylpyridine

: 685133-49-7
2-benzyloxymethyl-2-(6-tert-butoxycarbonylamino-5-methylpyridin-3-ylmethyl)malonic acid mono-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 59 percent / (PPh₃)2PdCl₂ / 1,2-dichloro-ethane / 48 h / 90 °C

2: 59 percent / Bu₄NF / tetrahydrofuran / 20 °C

3: 77 percent / PPh₃; CBr₄ / CH₂Cl₂ / 3 h / 0 - 20 °C

4: 59 percent / NaH / tetrahydrofuran / -70 - 20 °C

5: 60 percent / LDA / tetrahydrofuran; heptane; ethylbenzene / 0 - 20 °C

6: 60 percent / KOH / CH₂Cl₂; ethanol; H₂O / 96 h / 20 °C

With potassium hydroxide; carbon tetrabromide; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; ethylbenzene; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2003.12.039