Technology Process of [6-(4-METHOXYPHENYL)PYRIDIN-3-YL]METHANOL
There total 3 articles about [6-(4-METHOXYPHENYL)PYRIDIN-3-YL]METHANOL which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
3: diisobutylaluminium hydride / dichloromethane / 18.5 h / -78 - 20 °C
4: caesium carbonate; palladium diacetate; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt / 1,4-dioxane / 18 h / 130 °C / Inert atmosphere
With
di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jacs.8b09595
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
2: diisobutylaluminium hydride / dichloromethane / 18.5 h / -78 - 20 °C
3: caesium carbonate; palladium diacetate; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt / 1,4-dioxane / 18 h / 130 °C / Inert atmosphere
With
di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; diisobutylaluminium hydride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
1,4-dioxane; dichloromethane;
DOI:10.1021/jacs.8b09595
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / dichloromethane / 18.5 h / -78 - 20 °C
2: caesium carbonate; palladium diacetate; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt / 1,4-dioxane / 18 h / 130 °C / Inert atmosphere
With
di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; diisobutylaluminium hydride; caesium carbonate;
In
1,4-dioxane; dichloromethane;
DOI:10.1021/jacs.8b09595
