5-(2-CHLOROPHENYL)NICOTINALDEHYDE

Base Information

• Chemical Name: 5-(2-CHLOROPHENYL)NICOTINALDEHYDE
• CAS No.: 855301-00-7
• Molecular Formula: C₁₂H₈ClNO
• Molecular Weight: 217.655
• Hs Code.: 2933399090
• Mol file: 855301-00-7.mol

Synonyms:5-(2-CHLOROPHENYL)NICOTINALDEHYDE;5-(2-CHLOROPHENYL)PYRIDINE-3-CARBALDEHYDE;5-(2-Chlorophenyl)-3-pyridinecarbaldehyde

Chemical Property of 5-(2-CHLOROPHENYL)NICOTINALDEHYDE

Chemical Property:

• PSA: 29.96000
• LogP: 3.21450
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-(2-Chlorophenyl)-3-pyridinecarbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-CHLOROPHENYL)NICOTINALDEHYDE

There total 3 articles about 5-(2-CHLOROPHENYL)NICOTINALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2-chloro-phenyl)-nicotinic acid ethyl ester (855300-99-1) → 5-(2-chloro-phenyl)-pyridine-3-carbaldehyde (855301-00-7)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 3h;

DOI:10.1016/j.bmcl.2005.03.066

Reference yield:

ethyl 5-bromo-3-pyridinecarboxylate (20986-40-7) → 5-(2-chloro-phenyl)-pyridine-3-carbaldehyde (855301-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(Ph₃P)4; Na₂CO₃ / 12 h / 80 °C

2: DIBAL / CH₂Cl₂ / 3 h / -78 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisobutylaluminium hydride; sodium carbonate; In dichloromethane;

DOI:10.1016/j.bmcl.2005.03.066

Reference yield:

2-Chlorobenzeneboronic acid (3900-89-8) → 5-(2-chloro-phenyl)-pyridine-3-carbaldehyde (855301-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(Ph₃P)4; Na₂CO₃ / 12 h / 80 °C

2: DIBAL / CH₂Cl₂ / 3 h / -78 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisobutylaluminium hydride; sodium carbonate; In dichloromethane;

DOI:10.1016/j.bmcl.2005.03.066

upstream raw materials:

5-(2-chloro-phenyl)-nicotinic acid ethyl ester

ethyl 5-bromo-3-pyridinecarboxylate

2-Chlorobenzeneboronic acid

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